Email this article Lipemia after fat loading and atherosclerosis of coronary arteries: correlation of expression
- Authors: Bubnova MG1, Aronov DM1, Perova NV1, Mazaev VP1
-
Affiliations:
- ГНИЦ профилактической медицины Минздрава РФ
- Issue: Vol 79, No 6 (2004)
- Pages: 62-67
- Section: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/29845
- ID: 29845
Cite item
Full Text
Abstract
Aim. To examine relationships between lipemia, atherogenicity of blood lipoproteins spectrum after fat loading (FL) and severity of angiographic manifestations of coronary atherosclerosis. Material and methods. The study enrolled 72 males free of ischemic heart disease (IHD) - group 1; 60 IHD patients with moderate affection of the coronary arteries (CA), i.e. maximal narrowing of one CA 50% - group 2; 107 IHD patients with severe CA affection, i.e. CA narrowing > 50% - group 3. FL was given by J. R. Patsch technique, blood sampling was made before meal, 3 and 6 hours after FL.
Results. It was shown that intake of food fats in IHD and IHD-free patients stimulated development of postprandial lipemia of different severity and duration. It appeared due to increased fraction of lipoproteins rich in triglycerides. In group 2 and 3 there was a definite and up to 6 hours in duration postprandial hypertriglyceridemia associated with proatherogenic deviations in lipid and protein components (LDL and HDL) by FL hour 6: growing of LDL cholesterol, apoB, apoB/apoAI and lowering of HDL cholesterol and apoAI. Patients with severe CA atherosclerosis (> 50% narrowing of three CA) had the most severe atherogenic affections in the postprandial lipoprotein spectrum. Conclusion. Postprandial lipemia/hyperthglyceridemia and atherogenic changes in the spectrum of lipoproteins after FL correlate directly with angiographic manifestations of coronary atherosclerosis.
Results. It was shown that intake of food fats in IHD and IHD-free patients stimulated development of postprandial lipemia of different severity and duration. It appeared due to increased fraction of lipoproteins rich in triglycerides. In group 2 and 3 there was a definite and up to 6 hours in duration postprandial hypertriglyceridemia associated with proatherogenic deviations in lipid and protein components (LDL and HDL) by FL hour 6: growing of LDL cholesterol, apoB, apoB/apoAI and lowering of HDL cholesterol and apoAI. Patients with severe CA atherosclerosis (> 50% narrowing of three CA) had the most severe atherogenic affections in the postprandial lipoprotein spectrum. Conclusion. Postprandial lipemia/hyperthglyceridemia and atherogenic changes in the spectrum of lipoproteins after FL correlate directly with angiographic manifestations of coronary atherosclerosis.
About the authors
M G Bubnova
ГНИЦ профилактической медицины Минздрава РФМосква; ГНИЦ профилактической медицины Минздрава РФ
D M Aronov
ГНИЦ профилактической медицины Минздрава РФМосква; ГНИЦ профилактической медицины Минздрава РФ
N V Perova
ГНИЦ профилактической медицины Минздрава РФМосква; ГНИЦ профилактической медицины Минздрава РФ
V P Mazaev
ГНИЦ профилактической медицины Минздрава РФМосква; ГНИЦ профилактической медицины Минздрава РФ
References
- Assmann G., Gotto A. M., Paoletti R. The hypertriglyceridemias (Review). Am. J. Cardiol. 1991; 68: 1-42.
- Austin M. A. Plasma triglyceride and coronary heart disease (Review). Arterioscler. Thromb. 1991; 11: 2-14.
- Gotto A. M. Triglyceride: The forgotten risk factor. Circulation 1998; 97: 1027-1028.
- Davignon J., Conn J. Triglycerides: a risk factor for coronary heart disease (Review). Atherosclerosis 1996; 124 (suppl. 1): S57-S64.
- Hokanson J., Austin M. A. Plasma triglyceride level is an independent risk factor for cardiovascular disease: a meta-analysis of population based prospective studies. J. Cardiovasc. Risk. 1996; 3: 213-219.
- Zilversmit D. B. Atherogenesis: a postprandial phenomenon. Circulation 1979; 60: 473-484.
- Patsch J. R., Hopferwieser Т., Muhlberger V. et al. Postprandial lipemia in patients with coronary artery disease. Ibid. 1990; 82 (suppl. Ill): S284.
- Patsch J. R., Miesenbock G., Hopferwieser T. et al. Relation of triglyceride metabolism and coronary artery disease: studies in the postprandial state. Arterioscler. Thromb. 1992; 12: 1336-1345.
- Steiner G. Triglyceride-rich lipoproteins and atherosclerosis, from fast to feast. Ann. Med. 1993; 25: 431-435.
- Weintraub M. S., Grosskopf I., Rassin T. et al. Clearance of chylomicron remnants in normolipidaemic patients with coronary artery disease: case control study over three years. Brit. med. J. 1996; 312: 936-939.
- Karpe F., Steiner G., Uffelman K. et al. Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis 1994; 106: 83-97.
- Stampfer M. J., Krauss R. M., Blanche P. J. et al. A prospective study of triglyceride level, low = density lipoprotein particle diameter, and risk of myocardial infarction. J. A. M. A. 1996; 276: 882-888.
- Palsch J. R., Karlin J. В., Scolt L. W. et al. Inverse relationship between levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia. Proc. Natl. Acad. Sci. USA 1983; 80: 1449-1453.
- Patsch J. Influence of lipolysis on chylomicron clearance and HDL cholesterol levels. Eur. Heart'j. 1998; 19 (suppl. H): H2-H6.
- Parkard С. J., Shepherd J. Lipoprotein heterogeneity and apolipoprotein В metabolism. Arterioscler. Tromb. Vase. Biol. 1997; 17: 3543-3556.
- Phillips N. R., Water D., Havel R. J. Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events. Circulation 1993; 88: 2762.
- Eisenberg S. Relationship of HDL to other lipoproteins. In: Gotto A. M. et al., eds. High density lipoproteins and atherosclerosis. Amsterdam: Elsevier Press; 1978. 67-75.
- Wit A.-L., Windmueler H. G. Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat. J. Biol. Chem. 1979; 254: 7316-7322.
Supplementary files
