Email this article The role of presepsin in the diagnosis and assessment of severity of sepsis and severe pneumonia
- Authors: TItova EA1, Eyrikh AR2, Titova ZA1
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Affiliations:
- Subdepartment of therapy and general medical practice with course of further professional education of the Altai State Medical University
- Altai Regional Clinical Hospital
- Issue: Vol 90, No 11 (2018)
- Pages: 44-47
- Section: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/32876
- DOI: https://doi.org/10.26442/terarkh201890114-47
- ID: 32876
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Abstract
The aim of this study was to evaluate marker of inflammation presepsin to improve diagnosis of severe pneumonia, sepsis. Materials and methods. 75 patients with pneumonia, sepsis, other inflammatory diseases aged from 17 to 78 years were examined. These patients have been investigated for the level of the presepsin. Presepsin level was quantified on immunohemilyuministsentny analyzer Pathfast (Mitsubishi Chemical Medience Corporation, Japan) in pg/ml. All patients had obtained an antibacterial therapy in other health care organizations before entering the hospital. Results. Presepsin at the general group of patients with pneumogenic sepsis was 3196.9±1202.16 pg/mL (n=14, x̅±m), with abdominal sepsis - 2506.7±448.32 pg/mL (n=28), with other inflammatory diseases - 671.6±124.55 pg/mL (n=11). Presepsin of patients with pneumogenic sepsis was 1125.3±240.59 pg/mL (n=3), presepsin of patients with severe pneumonia was - 362.6±76.29 pg/mL (n=13, p<0.05), non-severe pneumonia - 157.3±33.02 pg/mL (n=9, p<0.05). Conclusion. The high level of presepsin is an indication of an active infectious disease and reflects the severity of the pneumonia and development of sepsis. Keeping a high level against the backdrop of earlier presepsin ongoing antibiotic therapy is an indication of their lack of effectiveness. A significant variability of presepsin should be taken into account.
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##article.viewOnOriginalSite##About the authors
E A TItova
Subdepartment of therapy and general medical practice with course of further professional education of the Altai State Medical University
Email: tea6419@yandex.ru
д.м.н., проф. каф. терапии и общей врачебной практики с курсом дополнительного профессионального образования ФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава России Barnaul, Russia
A R Eyrikh
Altai Regional Clinical Hospitalзав. лаб. экспресс-диагностики КГБУЗ «Краевая клиническая больница» Barnaul, Russia
Z A Titova
Subdepartment of therapy and general medical practice with course of further professional education of the Altai State Medical Universityк.м.н., доцент каф. анестезиологии, реаниматологии и клинической фармакологии с курсом дополнительного профессионального образования ФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава России Barnaul, Russia
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