Email this article Brachial artery responsiveness in patients with systemic lupus erythematosus and scleroderma systematica
- Authors: Vinogradov A.A.1, Shilkina N.P.1, Kostyreva N.A.1, Vinogradov AA2, Shilkina NP2, Kostyreva NA2
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Affiliations:
- Ярославская государственная медицинская академия
- Yaroslavl State Medical Academy
- Issue: Vol 82, No 1 (2010)
- Pages: 43-46
- Section: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/33394
- ID: 33394
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Abstract
Subjects and methods. Sixty-five patients, including 25 with SLE, 20 with SDS, and 20 with atherosclerosis (AS) obliterans of lower extremity peripheral arteries, were examined. A control group consisted of 30 apparently healthy individuals matched with the study groups for gender and age. The ultrasound technique described by D. Celermajer, et al. was employed to evaluate endothelium-dependent vasodilation (EIVD). Endothelium-independent vasodilation (EIVD) was assessed by the nitroglycerin test. The coefficient of BA susceptibility (CS) to reactive hyperemia was calculated.
Results. In all study patient groups EDVD values were significantly lower (7.3 ± 1.35% in SLE, 6.91 ± 0.9% in SDS, and 7.64 ± 1.9% in AS; p < 0.05) than in the controls (11.23 ± 1.1%). An adequate vascular bed response was found in 5 (20%) patients with SLE and in 2 (10%) patients with SDS. A paradoxical vasoconstrictor response to reactive hyperemia was encountered in 9 (36%) patients with SLE, 11 (55%) with SDS. In all the study groups, the patients had normal EIVD with lower CS. In SLE and SDS, CS was decreased than that in the controls. The impaired BA responsiveness in SLE and SDS significantly correlated with the duration and activity of the disease, Raynaud's syndrome, capillaritides, mean blood pressure, renal lesions, as well as with the laboratory values of the activity of inflammation and blood lipid composition.
Conclusion. In SLE and SDS, there was a reduction in EDVD and EIVD, as well as paradoxical vasoconstriction. CS is an independent indicator of endothelial dysfunction with the normal values of EIVD. Impaired BA responsiveness was associated with the course of systemic inflammation and severe lesion of organs.
About the authors
Aleksey Alekseevich Vinogradov
Ярославская государственная медицинская академия
Email: vinograd@fromru.com
канд. мед. наук, аспирант каф., каф. пропедевтики внутренних болезней ЯГМА; Ярославская государственная медицинская академия
Nataliya Petrovna Shilkina
Ярославская государственная медицинская академия
Email: shilkin39@mail.ru
д-р мед. наук, проф., зав. кафедрой пропедевтики внутренних болезней ЯГМА; Ярославская государственная медицинская академия
Natal'ya Aleksandrovna Kostyreva
Ярославская государственная медицинская академия
Email: kostyrevanatalya@yandex.ru
аспирант, каф. пропедевтики внутренних болезней ЯГМА; Ярославская государственная медицинская академия
A A Vinogradov
Yaroslavl State Medical AcademyYaroslavl State Medical Academy
N P Shilkina
Yaroslavl State Medical AcademyYaroslavl State Medical Academy
N A Kostyreva
Yaroslavl State Medical AcademyYaroslavl State Medical Academy
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