Email this article The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension
- Authors: Babanov S.A.1, Baraeva R.A.2, Strizhakov L.A.3, Moiseev S.V.3, Fomin V.V.3
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Affiliations:
- Samara State Medical University
- Samara Medical and Sanitary Unit №5 of the Kirovsky District
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 93, No 6 (2021)
- Pages: 693-698
- Section: Original articles
- URL: https://journal-vniispk.ru/0040-3660/article/view/75961
- DOI: https://doi.org/10.26442/00403660.2021.06.200880
- ID: 75961
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Abstract
Background. The article presents data on the state of cytokine regulation, indicators of endothelial damage when exposed to industrial vibration (general, local) and in combination with arterial hypertension.
Aim. To improve the quality of early diagnosis and prevention of vibration disease in an isolated course and its combination with arterial hypertension based on a study of the cytokine profile, biomarkers of endothelial dysfunction in this pathology.
Materials and methods. A comprehensive survey of 84 patients with isolated vibration disease from the effects of local, general, first, second degree and 61 patients with a combined course of vibration disease from the effects of local, general second degree vibration and arterial hypertension, 30 people in the control group without contact with industrial vibration and found healthy by medical examination. The levels of pro-inflammatory (IL-1β, IL-8, TNF-α) and anti-inflammatory cytokines (IL-4), biomarkers of endothelial damage (EDN-1, TGF-β1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor) were determined using the enzyme immunoassay method.
Results. The response of the immune system to the effects of industrial vibration is characterized by a cytokine imbalance – an increase in the level of pro-inflammatory cytokines (IL-1β, IL-8, TNF-α) and a decrease in the level of anti-inflammatory cytokine (IL-4). With a combined course of vibratory disease and arterial hypertension, the cytokine imbalance is characterized by an even more significant increase in serum IL-1β, IL-8, TNF-α and a decrease in serum IL-4 concentration. Endothelial dysfunction with WB from the action of both local and general vibration in combination with hypertension is characterized by a significant increase in serum EDN-1, TGF-β1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor.
Conclusion. The study of the cytokine profile, biomarkers of damage to the vascular endothelium in this pathology will allow for the early diagnosis of vascular disorders and to optimize preventive measures for workers in vibration-hazardous industries.
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##article.viewOnOriginalSite##About the authors
Sergei A. Babanov
Samara State Medical University
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-1667-737X
д-р мед. наук, проф., зав. каф. профессиональных болезней и клинической фармакологии им. засл. деят. науки РФ проф. В.В. Косарева ФГБОУ ВО СамГМУ
Russian Federation, SamaraRimma A. Baraeva
Samara Medical and Sanitary Unit №5 of the Kirovsky District
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-4502-4140
канд. мед. наук, зав. дневным стационаром ГБУЗ СО СМСЧ №5
Russian Federation, SamaraLeonid A. Strizhakov
Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-2291-6453
д-р мед. наук, рук. Центра профессиональной патологии, проф. каф. внутренних, профес- сиональных болезней и ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)
Russian Federation, MoscowSergei V. Moiseev
Sechenov First Moscow State Medical University (Sechenov University)
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-7232-4640
д-р мед. наук, проф., зав. каф. внутренних, профессиональных болезней и ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)
Russian Federation, MoscowViktor V. Fomin
Sechenov First Moscow State Medical University (Sechenov University)
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-2682-4417
чл.-кор. РАН, д-р мед. наук, проф., проректор по клинической работе и дополнительному профессиональному образованию, зав. каф. факультетской терапии №1, дир. Клиники факультетской терапии им. В.Н. Виноградова ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)
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