Email this article Cytokines in primary biliary cirrhosis (diagnostic and prognostic implications)
- Authors: Golovanova EV1, Ilchenko LY.1, Tsaregorodtseva ТM1, Serova TI1, Gudkova RB1
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Affiliations:
- ЦНИИ гастроэнтерологии
- Issue: Vol 79, No 2 (2004)
- Pages: 8-11
- Section: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/29737
- ID: 29737
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Abstract
Aim. To study concentrations of serum pro- and anti-inflammatory cytokines (CK), CK correlations with clinicobiochemical activity, diagnostic and prognostic implications in primary biliary cirrhosis (PBC).
Material and methods. Enzyme immunoassay has been used to study content of IL-1B, IL-4, IL-6, IL-8, TNF-a, INF-y in peripheral blood of 96 women aged 26 to 82 years (mean age 56.2 ± 12.6 years) with PBC (kits "Protein Contour", "Cytokine", St-Petersburg). The control group consisted of 20 healthy women matched by age.
Results. PBC is associated with changes in serum CK content correlating with the disease activity and stage. Elevated levels of proinflammatory IL-6, TNF-a, INF-y and anti-inflammatory IL-4. Conclusion. Definition of the cytokine spectrum in PBC has made a prognostic significance as it allows judging about the disease activity, stage and prognosis.
Material and methods. Enzyme immunoassay has been used to study content of IL-1B, IL-4, IL-6, IL-8, TNF-a, INF-y in peripheral blood of 96 women aged 26 to 82 years (mean age 56.2 ± 12.6 years) with PBC (kits "Protein Contour", "Cytokine", St-Petersburg). The control group consisted of 20 healthy women matched by age.
Results. PBC is associated with changes in serum CK content correlating with the disease activity and stage. Elevated levels of proinflammatory IL-6, TNF-a, INF-y and anti-inflammatory IL-4. Conclusion. Definition of the cytokine spectrum in PBC has made a prognostic significance as it allows judging about the disease activity, stage and prognosis.
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About the authors
E V Golovanova
ЦНИИ гастроэнтерологииМосква; ЦНИИ гастроэнтерологии
L Yu Ilchenko
ЦНИИ гастроэнтерологииМосква; ЦНИИ гастроэнтерологии
Т M Tsaregorodtseva
ЦНИИ гастроэнтерологииМосква; ЦНИИ гастроэнтерологии
T I Serova
ЦНИИ гастроэнтерологииМосква; ЦНИИ гастроэнтерологии
R B Gudkova
ЦНИИ гастроэнтерологииМосква; ЦНИИ гастроэнтерологии
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