Arterial hypertension in adolescents with different physical constitution including those with signs of metabolic syndrome

Aim. Detection of clinico-paraclinical features of arterial hypertension (AH) in adolescents with different
physical constitution including signs of metabolic syndrome (MS).
Material and methods. Blood levels of uric acid, cholesterol, triglycerides (TG), high and low density
lipoproteins were examined and glucose tolerance test was made in 108 adolescents with arterial hypertension
(AH) and different physical constitution (normal, with overweight and obese). Waist and
hip distribution of fat was assessed. The control group consisted of JOS healthy adolescents.
Results. Most of the hypertensive children had hyperuricemia (HU), some of the patients combined
HU with changes in glycemic profde of blood. The above abnormalities were especially evident in patients
with MS who were characterized by abdominal obesity, higher blood pressure, subnormal high
density lipoproteins, higher triglycerides and total cholesterol in blood, more severe HU and defects in
glycemic profde of blood.
Conclusion. MS in adolescents may be of genetic origin as well as constitutional HU and insulin resistance
may be mutually dependent signs combination of which with other factors presents the whole
spectrum of clinical and paraclinical manifestations of MS. Detection of HU and insulin resistance
with their correction in a preclinical disease stage (in children and adolescents) may represent a new
line in prevention of AH and MS in adults.

arterial hypertension, adolescents, metabolic syndrome, hyperuricemia, insulin resistance, visceral type of fat, obesity