电邮这篇文章 Lisinopril effects on cerebral blood flow and blood rheology in hypertensive patients
- 作者: Markova LI1, Kuznetsova IV1, Radzevich AE1
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隶属关系:
- Московский государственный медико-стоматологический университет
- 期: 卷 79, 编号 11 (2004)
- 页面: 41-43
- 栏目: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/29928
- ID: 29928
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Aim. To access the effect of lisinopril (diroton) on cerebral circulation and blood rheology in patients
with arterial hypertension stage II.
Material and methods. The trial included 37 patients (16 males, 21 females) with a mean arterial
hypertension (AH) history 15.9 ± 5.6 years. Diroton was given in a dose 10-40mg/dayfor 6 months.
Cerebral circulation (total cerebral circulation and venous outflow - TCC and VOF) was accessed by
means of doppler ultrasonography. Blood and plasm rheology was determined using a rotational viscozymeter ACP-2.
Instrumental tests were performed at baseline and at the end of the study.
Results. Rheology tests showed that diroton-treated patients achieved a significant decrease in blood
viscosity in high, moderate and low shear stress and plasma viscosity, a decrease in platelet aggregation
index and an increase in the index of erythrocytic deformability. All these changes were accompanied
with a significant fall in fibrinogen and hematocrit. Doppler ultrasound revealed an insignificant
increase in TCC and VOF.
Conclusion. Diroton significantly improved impaired blood rheology and viscosity in AH patients as
well as cerebral hemodynamics in patients with subnormal cerebral circulation and venous outflow at
baseline.
with arterial hypertension stage II.
Material and methods. The trial included 37 patients (16 males, 21 females) with a mean arterial
hypertension (AH) history 15.9 ± 5.6 years. Diroton was given in a dose 10-40mg/dayfor 6 months.
Cerebral circulation (total cerebral circulation and venous outflow - TCC and VOF) was accessed by
means of doppler ultrasonography. Blood and plasm rheology was determined using a rotational viscozymeter ACP-2.
Instrumental tests were performed at baseline and at the end of the study.
Results. Rheology tests showed that diroton-treated patients achieved a significant decrease in blood
viscosity in high, moderate and low shear stress and plasma viscosity, a decrease in platelet aggregation
index and an increase in the index of erythrocytic deformability. All these changes were accompanied
with a significant fall in fibrinogen and hematocrit. Doppler ultrasound revealed an insignificant
increase in TCC and VOF.
Conclusion. Diroton significantly improved impaired blood rheology and viscosity in AH patients as
well as cerebral hemodynamics in patients with subnormal cerebral circulation and venous outflow at
baseline.
作者简介
L Markova
Московский государственный медико-стоматологический университетМосковский государственный медико-стоматологический университет
I Kuznetsova
Московский государственный медико-стоматологический университетМосковский государственный медико-стоматологический университет
A Radzevich
Московский государственный медико-стоматологический университетМосковский государственный медико-стоматологический университет
参考
- Суслина З. А., Гераскина Л. А., Фонякин А. В. Артериальная гипертония и инсульт: патогенетическая взаимосвязь и перспективы профилактики. Кардиология 2001; 1: 5-7.
- Толпыгина С. Н., Ощепкова Е. В., Варакин Ю. Я. Мозговой кровоток при артериальной гипертонии. Кардиология 2001; 4: 71-77.
- Преображенский Д. В., Сидоренко Б. А., Носенко Е. М., Препатова Ю. В. Головной мозг как орган-мишень у больных гипертонической болезнью и антигипертензивная терапия. Кардиология 2000; 1: 83-88.
- Бритое А. Н., Быстрова М. М. Новые рекомендации Объединенного национального комитета по предупреждению, диагностике и лечению артериальной гипертонии (США): от JNC VI к JNC VII Кардиология 2003; 11: 93- 97.
- Лелюк В. Г., Лелюк С. Э. Ультразвуковая ангиология. М.; "Видар" 1998. 4: 185-220.
- Баркаган З. С., Мамот А. П. Диагностика и контролируемая терапия нарушений гемостаза. М.: Ньюдиамед; 2001.
- Collins R., Peto R. Antihypertensive therapy: effect on stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. J. A. M. A. 1991; 265: 3255-3264.
- Шмидт Р. Ф., Тьюз Г. (Schmidt R. F., Thews G.) Физиология человека. М. "Мир" 1996. 500-503.
- Шабанов В. А., Терехина Е. В., Костров В. А. Изменение реологических свойств крови у больных гипертонической болезнью. Тер. арх. 2001; 10: 70-73.
- Беленков Ю. Н., Мареев В. Ю., Агеев Ф. Т. Ингибиторы ангиотензинпревращающего фермента в лечении сердечно-сосудистых заболеваний. М. ЗАО "Информатик" 2001. 30-34.
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