电邮这篇文章 Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia
- 作者: KHASPEKOVA SG1, GOLOVKINA LL2, DONUSH EK3, GOLUBEVA NV1, SHUSTOVA ON1, MAZUROV AV1
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隶属关系:
- National Medical Research Center for Cardiology, Russian Ministry of Health
- National Medical Research Center for Hematology, Russian Ministry of Health
- Russian Pediatric Clinical Hospital, Russian Ministry of Health
- 期: 卷 90, 编号 7 (2018)
- 页面: 65-69
- 栏目: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/32783
- DOI: https://doi.org/10.26442/terarkh201890765-69
- ID: 32783
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The aim. Mechanisms underlying the development of neonatal alloimmune thrombocytopenia (NAIT) in in Russia have been studied. Materials and methods. Genetic polymorphisms of human platelet alloantigens (HPA) -1, -2, -3, -4, -5, and -15 were evaluated in 27 families having the newborns with NAIT. NAIT was diagnosed according to the following criteria: (1) newborn with thrombocytopenia; (2) mother with no thrombocytopenia and no increase of platelet associated IgG, (3) presence of antibodies reacting with paternal platelets in maternal plasma / serum. HPA genotyping revealed incompatibilities in 23 out of 27 tested families. In these 23 families HPA-1 conflicts were detected in 16 ones (70%). In 8 cases mothers were homozygous carriers of rare HPA-1b allele and in another 8 cases - of HPA-1a allele which cased incompatibilities with fetal HPA-1a and HPA-1b respectively. In 5 out of 23 families (22%) there were incompatibilities with fetal HPA-15 (HPA-15a, n=2 and HPA-15b, n=3), in 1 family - with HPA-5b (4%), and in 1 family - with HPA-3b (4%) alloantigens. In conclusion the main causes of NAIT in Russia were HPA-1a and -1b conflicts and HPA-15 conflicts were the second frequent ones.
作者简介
S KHASPEKOVA
National Medical Research Center for Cardiology, Russian Ministry of Health
Email: svkh@list.ru
к.б.н., с.н.с. Moscow, Russia
L GOLOVKINA
National Medical Research Center for Hematology, Russian Ministry of Healthд.м.н., врач-гематолог, рук. лаб. Moscow, Russia
E DONUSH
Russian Pediatric Clinical Hospital, Russian Ministry of Healthк.м.н., врач-гематолог, зав. отделением Moscow, Russia
N GOLUBEVA
National Medical Research Center for Cardiology, Russian Ministry of Healthн.с. Moscow, Russia
O SHUSTOVA
National Medical Research Center for Cardiology, Russian Ministry of Healthм.н.с. Moscow, Russia
A MAZUROV
National Medical Research Center for Cardiology, Russian Ministry of Healthд.б.н., проф., рук. лаб. Moscow, Russia
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