Onychomycosis: features external therapy
- Authors: Zaslavsky D.V.1, Chuprov I.N.2, Sidikov A.A.3, Khvedelidze M.G.1, Tatarskaya O.B.1
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Affiliations:
- St. Petersburg State Pediatric Medical University
- State Medical University by the name I.I. Mechnikov
- Leningrad Regional Center of specialized types of medical care
- Issue: Vol 92, No 5 (2016)
- Pages: 90-95
- Section: DRUG TREATMENT IN DERMATOVENEROLOGY
- URL: https://journal-vniispk.ru/0042-4609/article/view/116841
- DOI: https://doi.org/10.25208/0042-4609-2016-92-5-90-95
- ID: 116841
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Abstract
Onychomycosis - one of the most frequent diseases with defeat of a nail bed, matrics and nail plate of a fungal origin. Frequency of an onychomycosis in Russia reaches 5% (to 15 million people), and practically every tenth visit of the dermatologist is connected with this pathology. Treatment of an onychomycosis still remains very difficult task. Application of varnishes, ointments with antimycotics and local agents on an oil basis has an essential shortcoming - insufficient receipt of a preparation to the center of pathological changes. It is supposed that for optimum therapy it is necessary to influence: first, from frontal and distal part of a nail, secondly, to apply aqueous-alcoholic solutions of a preparation which can freely get into subnail spaces with the phenomena of an onycholysis. For example, it has been shown highly efficient application of naftifina a hydrochloride under control of solution of the diamond green, showing diffusion distribution active ingredient to subnail space and on channels.
About the authors
D. V. Zaslavsky
St. Petersburg State Pediatric Medical University
Author for correspondence.
Email: venerology@gmail.com
Russian Federation
I. N. Chuprov
State Medical University by the name I.I. Mechnikov
Email: venerology@gmail.com
Russian Federation
A. A. Sidikov
Leningrad Regional Center of specialized types of medical care
Email: venerology@gmail.com
Russian Federation
M. G. Khvedelidze
St. Petersburg State Pediatric Medical University
Email: venerology@gmail.com
Russian Federation
O. B. Tatarskaya
St. Petersburg State Pediatric Medical University
Email: venerology@gmail.com
Russian Federation
References
- Scher R.K., Coppa L.M. Advances in the diagnosis and treatment of onychomycosis. Hosp Med 1998; 34: 11-20.
- Lubeck D.P. Measuring health-related quality of life in onychomycosis. J Am Acad Dermatol 1998 May 38 (5 Pt 3): S64-8.
- Raznatovsky K.I., Rodionov A.N., Kotrekhova L.P. Dermatomikosis. SPb.: Publishing house SPbMAPO 2006; 184.
- Crissey J.T. Common dermatophyte infections. A simple diagnostic test and current management. Postgrad. Med 1998; 103 (2): 191-205.
- Cohen A.D., Medvesovsky E., Shalev R. et al. An independent comparison of terbinafine and itraconazole in the treatment of toenail onychomycosis. J Dermatolog Treat 2003 Dec; 14 (4): 237-42.
- Crawford F., Young P., Godfrey C. et al. Oral treatments for toenail onychomycosis: a systematic review. Arch Dermatol 2002 Jun; 138 (6): 811-6.
- Gorlanov I.A., Zaslavsky D.V., Milyavskaya I.R., Leina L.M., Olovyanishnikov O.V., Kulikova S.Yu. Pediatric dermatovenereology: Textbook. M: Academy 2012; 352
- Sergeev A.Y. Fungal nail infections. 2nd edition. National academy of mycology 2007; 164
- . Medvedeva T.V., Leina L.M. Onychomycosis: modern ideas of an etiology, epidemiology, methods of therapy. http://www.rusmedserv. com/mycology/html/onihomic.htm
- Carney C., Tosti A., Daniel R. et al. A new classification system for grading the severity of onychomycosis: Onychomycosis Severity Index. Arch Dermatol 2011 Nov; 147 (11): 1277-82.
- Gupta A.K., Daigle D., Foley K.A. The prevalence of culture-confirmed toenail onychomycosis in at-risk patient populations. J Eur Acad Dermatol Venereol 2015 June; 29 (6): 1039-1044.
- Zaias N. Onychomycosis. Arch Dermatol 1972; 105: 263-274.
- Carney C., Tosti A., Daniel R. et al. A new classification system for grading the severity of onychomycosis: Onychomycosis Severity Index. Arch Dermatol 2011 Nov; 147 (11): 1277-82.
- Seebacher C. et al. Onychomycosis. Mycoses 2007; 50: 321-327.
- Scher R.K. Onychomycosis: therapeutic update. J Am Acad Dermatol 1999; 40: 21-26.
- Sergeev A.Y., Sergeev Y.V. Fungal infections. The management for doctors. M: BING Press 2003; 440.
- Carney C., Tosti A., Daniel R., Scher R., Rich P., DeCoster J., Elewski B. A new classification system for grading the severity of onychomycosis: Onychomycosis Severity Index. Arch Dermatol 2011 Nov; 147 (11): 1277-82.
- The Russian Society of dermatologists and cosmetologists. Federal guidelines for the management of patients with mycosis hands, feet and trunk. M, 2015.
- Sergeev Y.V., Savchenko N.V., Sergeev A.Y. Opportunities and prospects of the local and combined therapy of onychomycosis in the second decade of the 21st century. Immunopathol allergol infektol 2012; 3: 73-80
- Burova S.A., Privolnev V.V. Onychomycosis: look of the dermatologist and surgeon. Rany i ranevii infeccii 2015; 2: 6-12
- Lykova S.G., Spitsyna A.V., Petrenko O.S. Local antimiсotiс therapy: detailed answers to topical issues. Ros med journ 2015; 5: 1-5
- Zhukova O.V. Modern methods of external therapy of onikhomikoz. Clin dermatol venerol 2012; 5: 1-3
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