A STUDY OF THE ROLE PLAYED BY THE POLYMORPHISM OF GENES ENCODING CYTOKINES IN THE DEVELOPMENT OF COMPLICATIONS OF THE UROGENITAL CHLAMYDIA INFECTION IN WOMEN
- Authors: Plakhova KI1
-
Affiliations:
- State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
- Issue: Vol 89, No 4 (2013)
- Pages: 44-51
- Section: Articles
- URL: https://journal-vniispk.ru/0042-4609/article/view/117064
- DOI: https://doi.org/10.25208/vdv607
- ID: 117064
Cite item
Full Text
Abstract
The author describes the results of a study of the polymorphism of genes encoding cytokines IL-6, IL-10, TnF-α, IFN-γ, TGF-β 1 and MBL2 in women suffering from the urogenital chlamydia infection (40 subjects), women with secondary infertility caused by the Chlamydia infection in the medical history (20 subjects) and clinically healthy women of childbearing potential (control group, 20 subjects). The SnapShot multiplex molecular and genetic method was used to study the polymorphism of genes. As a result of the study, the most frequent genotypes were revealed for each polymorphism of cytokine genes. reliable associations (0.01 < р < 0.001) were established between the frequency of individual genotypes (IL6*-174C/C, IL-10*-1082G/A, TGF-β 1*-915G/C, TGF-β 1*-869T/C and MBL2*-204G/G) and the onset of complications of the urogenital chlamydia infection, which makes it possible to exam ine these variants of genotypes as markers of an increased risk for the complicated course of the urogenital chlamydia infection resulting in reproductive disorders in women.
Full Text
##article.viewOnOriginalSite##About the authors
K I Plakhova
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
Email: plahova_xenia@mail.ru
к.м.н., старший научный сотрудник отдела инфекций, передаваемых половым путем 107076, москва, ул. Короленко, д. 3, стр. 6
References
- Resursy i deyatel'nost' meditsinskikh organizatsiy dermato-venerologicheskogo profilya. Zabolevaemost' infektsiyami, peredavaemymi polovym putem, zaraznymi kozhnymi boleznyami i boleznyami kozhi za 2010-2011 gody (Statisticheskie materialy). [Ресурсы и деятельность медицинских организаций дерматовенерологического профиля. Заболеваемость инфекциями, передаваемыми половым путем, заразными кожными болезнями и болезнями кожи за 2010-2011 гг. (Статистические материалы)]
- Ohman H., Triitinen A., Halttunen M. et al. Cytokine polymotphisms and severity of tubal damage in women with Chlamydia-associated infertility. H. Ohman. J. f infect dis. 2009; 199. 1353 -9.
- Hvid M., Baczynska A. , Deleuran B., Fedder J., Knudsen H., Christiansen G., Birkelund S. Interleukin-1 is the initiator of Fallopian tube destruction during Chlamydia trachomatis infection. Cell Microbiol 2007.
- Ohman H., Triitinen A., Halttunen M. et al. IL-10 polymorphism and cell-mediated immune response to Chlamydia trachomatis. H. Ohman. Genes and Immunity 2006, 7. 243-249.
- Fife M.S., Gutierrez A., Ogilvie E.M., Stock C.J., Samuel J.M., Thomson W., Mack L.F., Lewis C.M., Woo P. Novel IL10 gene family associations with systemic juvenile idiopathic arthritis. Arthritis Res Ther 2006; 8(5):R
Supplementary files
