Angiogenesis in mycosis fungoides: pathogenetic significance and therapeutic options
- Authors: Karamova A.E.1, Aulova K.M.1
-
Affiliations:
- State Research Center of Dermatovenereology and Cosmetology
- Issue: Vol 101, No 3 (2025)
- Pages: 17-27
- Section: REVIEWS
- URL: https://journal-vniispk.ru/0042-4609/article/view/310286
- DOI: https://doi.org/10.25208/vdv16873
- EDN: https://elibrary.ru/cshxqj
- ID: 310286
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Abstract
Mycosis fungoides is a primary epidermotropic cutaneous T-cell lymphoma characterized by proliferation of small and medium-sized T-lymphocytes with cerebriform nuclei. The pathogenesis of this disease is complex and has not been completely investigated, but angiogenesis plays a significant role. Angiogenesis is the process of forming new blood vessels based on an existing vascular network, which includes extracellular matrix remodeling, endothelial cell migration and proliferation, capillary bed cell differentiation, and formation of anastomoses. In case of mycosis fungoides, the best investigated markers of angiogenesis include CD31, CD34, angiogenin, angiopoietin-1, angiopoietin-2, VEGF-A, VEGF-C, PlGF, MMP-2, and MMP-9. The current data on the pathogenetic aspects of angiogenesis in patients with mycosis fungoides are encouraging, however the small and heterogeneous patient populations and the limited number of the pro- and anti-angiogenic factors investigated necessitate further researches. Angiogenesis markers can be considered as potential additional differential diagnostic criteria, prognostic signs, and therapeutic targets in patients with mycosis fungoides.
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##article.viewOnOriginalSite##About the authors
Arfenya E. Karamova
State Research Center of Dermatovenereology and Cosmetology
Email: karamova@cnikvi.ru
ORCID iD: 0000-0003-3805-8489
SPIN-code: 3604-6491
MD, Cand. Sci. (Med.), Assistant Professor
Russian Federation, MoscowKseniya M. Aulova
State Research Center of Dermatovenereology and Cosmetology
Author for correspondence.
Email: aulovaksenia@mail.ru
ORCID iD: 0000-0002-2924-3036
SPIN-code: 8310-7019
Dermatovenerologist
Russian Federation, MoscowReferences
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