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Synthesis and Antimicrobial Activity of 3-Acylmethylene-2-oxo-1,4-benzoxazine-6-sulfonic Acids and Their Sodium Salts
- Authors: Mishunina N.A.1, Gein V.L.1, Novikova V.V.1
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Affiliations:
- Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
- Issue: Vol 95, No 11-12 (2025)
- Pages: 542–546
- Section: Articles
- URL: https://journal-vniispk.ru/0044-460X/article/view/362179
- DOI: https://doi.org/10.7868/S3034559625110087
- ID: 362179
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Abstract
The reactions of para-hydroxy-meta-aminobenzene sulfonic acid with methyl esters of acylpyruvic acids were studied. Short-term boiling of equimolar amounts of the initial reagents in acetic acid in the presence of sodium acetate produces sodium salts of 3-acylmethylene-2-oxo-1,4-benzoxazine-6-sulfonic acids, the treatment of which with sulfuric acid leads to 3-acylmethylene-2-oxo-1,4-benzoxazine-6-sulfonic acids. Structure of the compounds was established on the basis of IR and 1Н NMR spectroscopy data. Antimicrobial activity of the obtained compounds was studied.
About the authors
N. A. Mishunina
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
ORCID iD: 0009-0008-3673-1071
Perm, Russia
V. L. Gein
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
Email: geinvl48@mail.ru
ORCID iD: 0000-0002-8512-0399
Perm, Russia
V. V. Novikova
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
ORCID iD: 0000-0003-4475-4421
Perm, Russia
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