Increase in histone acetylation rescues a weak remote fear memory in rats

A. Kh. Vinarskaya; Винарская А. Х.; P. M. Balaban; Балабан П. М.; A. B. Zuzina; Зюзина А. Б.

doi:10.31857/S0044467723060138

Увеличение ацетилирования гистонов способствует восстановлению слабой отставленной памяти у крыс

Авторы: Винарская А.Х.¹, Балабан П.М.¹, Зюзина А.Б.¹
Учреждения:
1. Федеральное государственное бюджетное учреждение науки Институт высшей нервной деятельности и нейрофизиологии РАН
Выпуск: Том 73, № 6 (2023)
Страницы: 809-818
Раздел: ФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ ПОВЕДЕНИЯ ЖИВОТНЫХ: ВОСПРИЯТИЕ ВНЕШНИХ СТИМУЛОВ, ДВИГАТЕЛЬНАЯ АКТИВНОСТЬ, ОБУЧЕНИЕ И ПАМЯТЬ
URL: https://journal-vniispk.ru/0044-4677/article/view/233012
DOI: https://doi.org/10.31857/S0044467723060138
EDN: https://elibrary.ru/AUOCKZ
ID: 233012

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Аннотация
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Аннотация

Согласно современным представлениям ингибиторы гистондеацетилаз (ГДАЦ) способны улучшать память у различных видов животных. Однако до сих пор не ясно, может ли повышенное ацетилирование гистонов способствовать улучшению слабой отставленной памяти у крыс. Таким образом, целью настоящего исследования было изучение способности ингибитора ГДАЦ бутирата натрия (БН) улучшать слабую отставленную память о страхе у крыс. Чтобы оценить способность ингибитора ГДАЦ БН улучшать отставленную память, мы сравнили поведение двух лабораторных линий крыс, Wistar и Long-Evans, в задаче условно-рефлекторного страха через шесть месяцев после обучения до и после введения БН. Мы обнаружили, что животные демонстрировали хорошую обстановочную память через 24 ч после окончания обучения, полное отсутствие памяти через 6 мес. и улучшенную условно-рефлекторную память после введения БН без дополнительного обучения. Более того, полученные данные продемонстрировали, что обе линии крыс показали одинаковое снижение реакции замирания с течением времени, а ингибирование ГДАЦ улучшало слабую память у обеих линий. Кроме того, ослабление и восстановление памяти у самцов полностью соответствовало изменениям памяти у самок крыс. Эти результаты показывают, что ингибирование ГДАЦ оказывает одинаковый “восстанавливающий” эффект на слабую отставленную условно-рефлекторную память о страхе, независимо от линии и пола крыс.

Ключевые слова

бутират натрия, ацетилирование гистонов, эпигенетика, отставленная память, восстановление памяти, реконсолидация

Список литературы

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