Email this article Arrhenius Kinetics As a Bioactivity Assessment Criterion for Drug Substances and Excipients
- Authors: Levitskaya O.V.1, Syroeshkin A.V.1, Pleteneva T.V.1
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Affiliations:
- Russian University of People’s Friendship, 8 Miklukho-Maklaya St.
- Issue: Vol 49, No 11 (2016)
- Pages: 779-781
- Section: Article
- URL: https://journal-vniispk.ru/0091-150X/article/view/244291
- DOI: https://doi.org/10.1007/s11094-016-1370-9
- ID: 244291
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Abstract
Arrhenius kinetic principles, in particular, Ea values, were used to assess the biological activity of drug substances in aqueous solutions with different D/H ratios. The obtained activation energies indicated that deuterium-depleted solutions had lower toxicity and biological activity.
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About the authors
O. V. Levitskaya
Russian University of People’s Friendship, 8 Miklukho-Maklaya St.
Author for correspondence.
Email: titorovicholga@gmail.com
Russian Federation, Moscow, 117198
A. V. Syroeshkin
Russian University of People’s Friendship, 8 Miklukho-Maklaya St.
Email: titorovicholga@gmail.com
Russian Federation, Moscow, 117198
T. V. Pleteneva
Russian University of People’s Friendship, 8 Miklukho-Maklaya St.
Email: titorovicholga@gmail.com
Russian Federation, Moscow, 117198
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