Email this article Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride
- Authors: Krylov V.I.1, Moiseev S.V.1, Kutin A.A.1, Sakhno N.G.1, Gunar O.V.1, Yashkir V.A.1, Merkulov V.A.1
-
Affiliations:
- Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- Issue: Vol 49, No 12 (2016)
- Pages: 821-824
- Section: Article
- URL: https://journal-vniispk.ru/0091-150X/article/view/244300
- DOI: https://doi.org/10.1007/s11094-016-1379-0
- ID: 244300
Cite item
Open Access
Access granted
Subscription Access
Abstract
An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.
About the authors
V. I. Krylov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Russian Federation, Moscow, 127051
S. V. Moiseev
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Author for correspondence.
Email: MoissevSV@expmed.ru
Russian Federation, Moscow, 127051
A. A. Kutin
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Russian Federation, Moscow, 127051
N. G. Sakhno
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Russian Federation, Moscow, 127051
O. V. Gunar
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Russian Federation, Moscow, 127051
V. A. Yashkir
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Russian Federation, Moscow, 127051
V. A. Merkulov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: MoissevSV@expmed.ru
Russian Federation, Moscow, 127051
Supplementary files
