Effect of Serratula Coronata Extract on Apoptosis Activity in Rats
- Авторы: Selyaskin K.E.1, Sidorova Y.S.1, Zorin S.N.1, Vasilevskaya L.S.1, Volodina S.O.2, Volodin V.V.2, Mazo V.K.1
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Учреждения:
- Scientific Research Institute of Nutrition, Russian Academy of Medical Sciences
- Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- Выпуск: Том 50, № 5 (2016)
- Страницы: 315-319
- Раздел: Medicinal Plants
- URL: https://journal-vniispk.ru/0091-150X/article/view/244380
- DOI: https://doi.org/10.1007/s11094-016-1443-9
- ID: 244380
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Аннотация
Phytoecdysteroids (at doses of 5 and 15 mg/kg of body mass per day) in the aqueous extract of Serratula coronata L. were administered toWistar rats for 15 d, did not have adverse effects on the thymus, and did not increase apoptosis rat in heart, brain, and thymus cells. The apoptosis rate in thymus cells of animals exposed to an electric shock increased statistically significantly relative to intact controls. The thymus mass did not decrease statistically significantly in stressed rats that received the phytoecdysteroid extract as compared with stressed animals that did not receive it. The apoptosis rate characterized by the DNA-damage level and number of apoptotic cells was also diminished in the thymus of stressed rats that received the extract. The results confirmed the safety of using phytoecdysteroid extracts in food and indicated that this extract inhibited the general adaptation syndrome of the rats.
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Об авторах
K. Selyaskin
Scientific Research Institute of Nutrition, Russian Academy of Medical Sciences
Email: chem@folium.ru
Россия, Moscow, 109240
Yu. Sidorova
Scientific Research Institute of Nutrition, Russian Academy of Medical Sciences
Email: chem@folium.ru
Россия, Moscow, 109240
S. Zorin
Scientific Research Institute of Nutrition, Russian Academy of Medical Sciences
Email: chem@folium.ru
Россия, Moscow, 109240
L. Vasilevskaya
Scientific Research Institute of Nutrition, Russian Academy of Medical Sciences
Email: chem@folium.ru
Россия, Moscow, 109240
S. Volodina
Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chem@folium.ru
Россия, Syktyvkar, Komi Republic, 167982
V. Volodin
Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chem@folium.ru
Россия, Syktyvkar, Komi Republic, 167982
V. Mazo
Scientific Research Institute of Nutrition, Russian Academy of Medical Sciences
Email: chem@folium.ru
Россия, Moscow, 109240
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