Email this article Rapid HPLC-MS/MS Determination of Carbamazepine and Carbamazepine-10,11-Epoxide
- Authors: Rodina T.A.1,2, Mel’nikov E.S.3,2, Sokolov A.V.1,3, Prokof’ev A.B.1,3,2, Arkhipov V.V.1,3,2, Aksenov A.A.3, Pozdnyakov D.L.2
-
Affiliations:
- Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation
- I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
- I. M. Sechenov First Moscow State Medical University
- Issue: Vol 50, No 6 (2016)
- Pages: 419-423
- Section: Article
- URL: https://journal-vniispk.ru/0091-150X/article/view/244408
- DOI: https://doi.org/10.1007/s11094-016-1462-6
- ID: 244408
Cite item
Open Access
Access granted
Subscription Access
Abstract
A rapid HPLC-MS/MS method for simultaneous determination of carbamazepine and carbamazepine- 10,11-epoxide in human blood serum was developed. The analytical range for carbamazepine was 50 – 20,000 ng/mL; for carbamazepine-10,11-epoxide, 5 – 2,000 ng/mL. This allowed the developed method to be used for therapeutic drug monitoring, bioequivalence studies, and an assessment of the interchangeability of carbamazepine preparations.
About the authors
T. A. Rodina
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Russian Federation, Moscow, 127051; Moscow, 109240
E. S. Mel’nikov
I. M. Sechenov First Moscow State Medical University; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Russian Federation, Moscow, 119991; Moscow, 109240
A. V. Sokolov
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, Moscow, 127051; Moscow, 119991
A. B. Prokof’ev
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Russian Federation, Moscow, 127051; Moscow, 119991; Moscow, 109240
V. V. Arkhipov
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Russian Federation, Moscow, 127051; Moscow, 119991; Moscow, 109240
A. A. Aksenov
I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Russian Federation, Moscow, 119991
D. L. Pozdnyakov
I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Russian Federation, Moscow, 109240
Supplementary files
