Synthesis and Analgesic Activity of 1-substituted 3-methyl-6-methoxy-7( n -butoxy)-3,4-dihydroisoquinolines

O. V. Surikova; A. S. Yusov; R. R. Makhmudov; A. G. Mikhailovskii

doi:10.1007/s11094-017-1549-8

Synthesis and Analgesic Activity of 1-substituted 3-methyl-6-methoxy-7(n-butoxy)-3,4-dihydroisoquinolines

Authors: Surikova O.V.¹, Yusov A.S.¹, Makhmudov R.R.², Mikhailovskii A.G.¹
Affiliations:
1. Perm State Pharmaceutical Academy
2. Perm State Science Research Institute University
Issue: Vol 51, No 1 (2017)
Pages: 18-21
Section: Article
URL: https://journal-vniispk.ru/0091-150X/article/view/244496
DOI: https://doi.org/10.1007/s11094-017-1549-8
ID: 244496

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Abstract

Cyclocondensation of O-butylated eugenol with various nitriles was used to synthesize 1-substituted derivatives of 3-methyl-6-methoxy-7-(n-butoxy)-3,4-dihydroisoquinoline. Hydrochlorides of the study compounds were tested for analgesic activity using the “hot plate” test. The experiments showed that the study compounds had analgesic effects greater than those of metamizole sodium and similar to those of ibuprofen.