Preparation and Antiproliferative Activity of Glucose – Acetylsalicylic Acid Conjugate


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Abstract

In this work, acetylsalicylic acid was used as the lead compound and its structure was modified by glycosylation. Glucose-based acetylsalicylic acid conjugate was prepared by using α-D-glucopyranosyl bromide as glycosyl donor and acetylsalicylic acid as acceptor. The proposed experimental procedure is simple and reproducible, providing a high yield and having great practical value. It is shown by MTT method that the glycosylated acetylsalicylic acid can inhibit in dose-dependent manner the proliferation of cancer cells.

About the authors

Gangliang Huang

College of Chemistry, Chongqing Normal University

Author for correspondence.
Email: huangdoctor226@163.com
China, Chongqing, 401331

Hui Gao

College of Chemistry, Chongqing Normal University

Email: huangdoctor226@163.com
China, Chongqing, 401331

Chengkun Yi

College of Chemistry, Chongqing Normal University

Email: huangdoctor226@163.com
China, Chongqing, 401331

Yanqiu Ai

College of Chemistry, Chongqing Normal University

Email: huangdoctor226@163.com
China, Chongqing, 401331

Dan Huang

College of Chemistry, Chongqing Normal University

Email: huangdoctor226@163.com
China, Chongqing, 401331

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