Email this article Synthesis, Immunomodulating and Antitumor Activities of Copolymers of Dialkylaminoethyl Methacrylates and Vinylsaccharides
- Authors: Nazarova O.V.1, Potapenkova L.S.2, Stukov A.N.2, Zolotova Y.I.1, Zhuravskaya O.N.1, Nekrasova T.N.1, Panarin E.F.1,3
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Affiliations:
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
- Peter the Great St. Petersburg Polytechnic University
- Issue: Vol 51, No 4 (2017)
- Pages: 245-249
- Section: Search for New Drugs
- URL: https://journal-vniispk.ru/0091-150X/article/view/244555
- DOI: https://doi.org/10.1007/s11094-017-1591-6
- ID: 244555
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Abstract
Water-soluble random copolymers of N,N-(dimethylamino)ethyl methacrylate or N,N-(diethylamino)ethyl methacrylate with vinylsaccharides (N-methacryloyl aminoglucose, 3-O-methacryloyl glucose, 1-O-methacryloyl sorbose) were synthesized. The copolymers differed in composition, structure of the carbohydrate fragment, and type of carbohydrate–main-polymer-chain bonds. The immunomodulating activity and antitumor properties of the synthesized copolymers were established. Copolymers containing sorbose residues possessed the most pronounced immunodepressant properties.
About the authors
O. V. Nazarova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Russian Federation, 31 Bol’shoi Prosp., St. Petersburg, 199004
L. S. Potapenkova
N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
Email: stukov2008@yandex.ru
Russian Federation, 68 Leningradskaya St., Pesochnyi, St. Petersburg, 197758
A. N. Stukov
N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
Author for correspondence.
Email: stukov2008@yandex.ru
Russian Federation, 68 Leningradskaya St., Pesochnyi, St. Petersburg, 197758
Yu. I. Zolotova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Russian Federation, 31 Bol’shoi Prosp., St. Petersburg, 199004
O. N. Zhuravskaya
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Russian Federation, 31 Bol’shoi Prosp., St. Petersburg, 199004
T. N. Nekrasova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Russian Federation, 31 Bol’shoi Prosp., St. Petersburg, 199004
E. F. Panarin
Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
Email: stukov2008@yandex.ru
Russian Federation, 31 Bol’shoi Prosp., St. Petersburg, 199004; 29 Politekhnicheskaya St., St. Petersburg, 195251
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