Use of Mathematical Planning Methods for Selecting Optimum Combined Gel Compositions

Abstract

Science-based selection of the base-carrier for a combined gel dosage form containing phenylacetic-acid derivatives was studied. One-factor dispersion analysis with repeated observations was used. For this, gels with nine bases were prepared and characterized qualitatively. According to the results, one composition was eliminated from further experiments because of thermal instability. The release of active substances (benzketozone and diclofenac sodium) from the proposed gels was determined by Kruvchinsky equilibrium dialysis. The experiments confirmed that the base-carrier type influences significantly the release of active substances from gel compositions. Dispersion analysis results showed that a carrier based on Carbomer 934P gave the optimum release of active substances.