Seasonal Oscillations in Statistical Mean Measures of Blood Composition and Blood Cell Morphology in Healthy White Rats

A. S. Pushkin; E. D. Drugova; S. A. Kamshilin; N. V. Obraztsov; O. V. Polekhina; S. I. Dvoretskaya; A. I. Churyumova

doi:10.1007/s11094-017-1692-2

Seasonal Oscillations in Statistical Mean Measures of Blood Composition and Blood Cell Morphology in Healthy White Rats

Авторы: Pushkin A.S.¹, Drugova E.D.¹, Kamshilin S.A.¹, Obraztsov N.V.¹, Polekhina O.V.¹, Dvoretskaya S.I.¹, Churyumova A.I.¹
Учреждения:
1. State Science Research Institute of Organic Chemistry and Technology
Выпуск: Том 51, № 9 (2017)
Страницы: 777-782
Раздел: Article
URL: https://journal-vniispk.ru/0091-150X/article/view/244799
DOI: https://doi.org/10.1007/s11094-017-1692-2
ID: 244799

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Аннотация

The aim of the present work was to identify seasonal oscillations in the composition and morphology of the blood in intact rats. Morphometric measures of blood were determined in 36 clinically healthy adult male rats in different seasons (spring, summer, and autumn) using the Mekos programmable system. Seasonal oscillations within established reference ranges were found and these need to be considered when performing preclinical studies of medicines in relation to their efficacy and safety.