Email this article Influence of New Promising Analgesic Compounds on Locomotor Activity of Mice
- Authors: Palikova Y.A.1,2, Skobtsova L.A.1,2, Zharmukhamedova T.Y.1, Palikov V.A.1,2, Rudenko V.B.1, Khokhlova O.N.1,3, Lobanov A.V.1,3, Rzhevskii D.I.1,3, Slashcheva G.A.1, D’yachenko E.V.2, Belous G.I.2, Andreev Y.A.4,5, Logashina Y.A.4,5, Kozlov S.A.4, Yavorskii A.N.2, Elyakova E.G.4, D’yachenko I.A.1,3,2
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Affiliations:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences
- Pushchino State Institute of Natural Sciences
- Pushchino Scientific Center, Russian Academy of Sciences
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Institute of Molecular Medicine, I. M. Sechenov First Moscow State Medical University
- Issue: Vol 52, No 8 (2018)
- Pages: 700-703
- Section: Article
- URL: https://journal-vniispk.ru/0091-150X/article/view/245419
- DOI: https://doi.org/10.1007/s11094-018-1884-4
- ID: 245419
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Abstract
The influence of new promising peptide (APCH3 and PT1) and nonpeptide analgesics (sevanol) on the behavior of male ICR mice was studied. All studied compounds at doses producing significant analgesic effects did not influence the behavior of mice in open-field tests. However, APCH at doses 10,000 times greater than the pharmacologically active dose produced sedative effects. Also, sevanol at a dose of 35 mg/kg caused statistically significant behavioral changes relative to the pharmacologically active dose (1 mg/kg) but not to the controls.
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About the authors
Yu. A. Palikova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290; 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
L. A. Skobtsova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290; 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
T. Yu. Zharmukhamedova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
V. A. Palikov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290; 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
V. B. Rudenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
O. N. Khokhlova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290; 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
A. V. Lobanov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290; 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
D. I. Rzhevskii
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290; 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
G. A. Slashcheva
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
E. V. D’yachenko
Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
G. I. Belous
Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
Ya. A. Andreev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Institute of Molecular Medicine, I. M. Sechenov First Moscow State Medical University
Email: dyachenko@bibch.ru
Russian Federation, 16/10 Miklukho-Maklaya St., Moscow, 117997; 8 Trubetskaya St., Moscow, 119991
Yu. A. Logashina
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Institute of Molecular Medicine, I. M. Sechenov First Moscow State Medical University
Email: dyachenko@bibch.ru
Russian Federation, 16/10 Miklukho-Maklaya St., Moscow, 117997; 8 Trubetskaya St., Moscow, 119991
S. A. Kozlov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 16/10 Miklukho-Maklaya St., Moscow, 117997
A. N. Yavorskii
Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
E. G. Elyakova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 16/10 Miklukho-Maklaya St., Moscow, 117997
I. A. D’yachenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Author for correspondence.
Email: dyachenko@bibch.ru
Russian Federation, 6 Prospekt Nauki, Pushchino, Moscow Oblast, 142290; 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290; 3 Prospekt Nauki, Pushchino, Moscow Oblast, 142290
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