Joint Mechanical Processing of a Drug Substance with Enterosorbent

Resumo

A selective enterosorbent (ES) based on natural silk fibroin with detoxification properties superior to those of traditional carbon sorbents (SKN-2K, SKN-4M) was proposed. The ES could be used as a matrix for drugs and a platform for new dosage forms to enhance the sanitizing effect of the proposed ES. Inclusion complexes of the ES with benzimidazolyl-2-methylcarbamate hydrochloride (I) were obtained and investigated. H-bonds were shown to form during the reaction of ES with I.