电邮这篇文章 Synthesis of C5-C6 Derivatives of 1,3-Dimethyl-5-Fluorouracil and 5-Fluorouracil. Screening for Antiviral Activity
- 作者: Chernikova I.B.1, Khursan S.L.1, Eropkin M.Y.2, Yunusov M.S.1
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隶属关系:
- Ufa Institute of Chemistry, Ufa Scientific Center, Russian Academy of Sciences
- Research Institute of Influenza, Ministry of Healthcare of the Russian Federation
- 期: 卷 53, 编号 2 (2019)
- 页面: 108-112
- 栏目: Search for New Drugs
- URL: https://journal-vniispk.ru/0091-150X/article/view/245624
- DOI: https://doi.org/10.1007/s11094-019-01962-9
- ID: 245624
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详细
5-Chloro-5-fluoro-6-alkoxypyrimidines were synthesized via Cl2 chlorination of 5-fluorouracil and 1,3-dimethyl-5-fluorouracil in various alcohols and were screened for antiviral activity. High antiviral activity was found for 5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil against RS virus and human flu viruses A/H3N2 and A/H1N1pdm09.
作者简介
I. Chernikova
Ufa Institute of Chemistry, Ufa Scientific Center, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: inna.b.chernikova@yandex.ru
俄罗斯联邦, 71 Prosp. Oktyabrya, Ufa, 450054
S. Khursan
Ufa Institute of Chemistry, Ufa Scientific Center, Russian Academy of Sciences
Email: inna.b.chernikova@yandex.ru
俄罗斯联邦, 71 Prosp. Oktyabrya, Ufa, 450054
M. Eropkin
Research Institute of Influenza, Ministry of Healthcare of the Russian Federation
Email: inna.b.chernikova@yandex.ru
俄罗斯联邦, 15/17 Prof. Popova St., St. Petersburg, 197376
M. Yunusov
Ufa Institute of Chemistry, Ufa Scientific Center, Russian Academy of Sciences
Email: inna.b.chernikova@yandex.ru
俄罗斯联邦, 71 Prosp. Oktyabrya, Ufa, 450054
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