Email this article Synthesis and Cardiotropic Activity of 1-(Methoxybenzyl)-4-{2-[(Methoxybenzyl)-Amino]Ethyl}Piperazines
- Authors: Mokrov G.V.1, Likhosherstov A.M.1, Barchukov V.V.1, Stolyaruk V.N.1, Tsorin I.B.1, Vititnova M.B.1, Rebeko A.G.1, Kryzhanovskii S.A.1, Gudasheva T.A.1
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Affiliations:
- V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- Issue: Vol 53, No 9 (2019)
- Pages: 786-791
- Section: Search for New Drugs
- URL: https://journal-vniispk.ru/0091-150X/article/view/246009
- DOI: https://doi.org/10.1007/s11094-019-02080-2
- ID: 246009
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Abstract
A group of new 1-(methoxybenzyl)-4-{2-[(methoxybenzyl)amino]ethyl}piperazines (1) were synthesized. The relationship of the structure of the triazaalkane linker and the cardiotropic activity in a series of these compounds was compared with that of previously studied linear and cyclic methoxyphenyltriazaalkanes. The most active compound in the group was 1e (1-(3,4,5-trimethoxybenzyl)-4-{2-[(3,4,5-trimethoxybenzyl)amino] ethyl}piperazine trihydrochloride) with statistically significant antiarrhythmic activity in aconitine and CaCl2 arrhythmia models.
About the authors
G. V. Mokrov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Author for correspondence.
Email: g.mokrov@gmail.come
Russian Federation, 8 Baltiiskaya St., Moscow, 125315
A. M. Likhosherstov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Russian Federation, 8 Baltiiskaya St., Moscow, 125315
V. V. Barchukov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Russian Federation, 8 Baltiiskaya St., Moscow, 125315
V. N. Stolyaruk
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Russian Federation, 8 Baltiiskaya St., Moscow, 125315
I. B. Tsorin
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Russian Federation, 8 Baltiiskaya St., Moscow, 125315
M. B. Vititnova
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Russian Federation, 8 Baltiiskaya St., Moscow, 125315
A. G. Rebeko
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Russian Federation, 8 Baltiiskaya St., Moscow, 125315
S. A. Kryzhanovskii
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Russian Federation, 8 Baltiiskaya St., Moscow, 125315
T. A. Gudasheva
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Russian Federation, 8 Baltiiskaya St., Moscow, 125315
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