Email this article Chemoprevention of Radiation-Induced Carcinogenesis Using Decoction of Meadowsweet (Filipendula Ulmaria) Flowers
- Authors: Bespalov V.G.1,2, Baranenko D.A.2, Aleksandrov V.A.1,2, Semenov A.L.1,3,2, Kovan’ko E.G.3, Ivanov S.D.3
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Affiliations:
- N. N. Petrov Research Institute of Oncology, Ministry of Health of the RF
- St. Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University)
- Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the RF
- Issue: Vol 52, No 10 (2019)
- Pages: 860-862
- Section: Article
- URL: https://journal-vniispk.ru/0091-150X/article/view/245511
- DOI: https://doi.org/10.1007/s11094-019-1915-9
- ID: 245511
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Abstract
The ability of the decoction of meadowsweet flowers (Filipendula ulmaria, FU) to inhibit tumor development in female LIO rats was demonstrated using a radiation-induced carcinogenesis model (single γ-radiation dose of 4 Gy). Over half of tumors that developed in various locations in most (79.6%) irradiated control rats were malignant. The tumors were most often located in the breast. The carcinogenesis parameters for all locations (multiplicity of all tumors and incidence of malignant tumors) and especially for breast tumors (number of tumor-bearing rats, multiplicity of all and only malignant tumors) were reduced considerably in irradiated rats that received FU with drinking water over 16 months.
About the authors
V. G. Bespalov
N. N. Petrov Research Institute of Oncology, Ministry of Health of the RF; St. Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University)
Author for correspondence.
Email: bespalov_niio@mail.ru
Russian Federation, St. Petersburg, 197758; St. Petersburg, 197101
D. A. Baranenko
St. Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University)
Email: bespalov_niio@mail.ru
Russian Federation, St. Petersburg, 197101
V. A. Aleksandrov
N. N. Petrov Research Institute of Oncology, Ministry of Health of the RF; St. Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University)
Email: bespalov_niio@mail.ru
Russian Federation, St. Petersburg, 197758; St. Petersburg, 197101
A. L. Semenov
N. N. Petrov Research Institute of Oncology, Ministry of Health of the RF; Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the RF; St. Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University)
Email: bespalov_niio@mail.ru
Russian Federation, St. Petersburg, 197758; St. Petersburg, 197758; St. Petersburg, 197101
E. G. Kovan’ko
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the RF
Email: bespalov_niio@mail.ru
Russian Federation, St. Petersburg, 197758
S. D. Ivanov
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the RF
Email: bespalov_niio@mail.ru
Russian Federation, St. Petersburg, 197758
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