Отправить статью по E-mail Synthesis and Tuberculostatic Activity of 2-Alkyl-5-Aryltetrazoles
- Авторы: Ishmetova R.I.1,2, Tolshchina S.G.1, Ignatenko N.K.1, Kravchenko M.A.3, Skornyakov S.N.3, Rusinov G.L.1,2, Charushin V.N.1,2
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Учреждения:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
- B. N. Yeltsin Ural Federal University
- Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
- Выпуск: Том 52, № 4 (2018)
- Страницы: 304-307
- Раздел: Article
- URL: https://journal-vniispk.ru/0091-150X/article/view/245148
- DOI: https://doi.org/10.1007/s11094-018-1811-8
- ID: 245148
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Аннотация
2-Substituted 5-aryltetrazoles containing alkyl and aminoalkyl fragments were synthesized using alkylation and Mannich reactions. The tuberculostatic activity of the synthesized compounds against strain M. tuberculosis H37Rv was studied. Pronounced tuberculostatic activity (MIC ≤ 1.5 ìg/mL) was found for tetrazoles containing N(2) dimethyl- and diethylaminoethyl fragments.
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R. Ishmetova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
Россия, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
S. Tolshchina
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Email: chem@folium.ru
Россия, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137
N. Ignatenko
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Email: chem@folium.ru
Россия, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137
M. Kravchenko
Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, 50 XXIInd Parts”ezda St, Ekaterinburg, 620039
S. Skornyakov
Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Россия, 50 XXIInd Parts”ezda St, Ekaterinburg, 620039
G. Rusinov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
Россия, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
V. Charushin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
Россия, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
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