Email this article Synthesis and Tuberculostatic Activity of 2-Alkyl-5-Aryltetrazoles
- Authors: Ishmetova R.I.1,2, Tolshchina S.G.1, Ignatenko N.K.1, Kravchenko M.A.3, Skornyakov S.N.3, Rusinov G.L.1,2, Charushin V.N.1,2
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Affiliations:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
- B. N. Yeltsin Ural Federal University
- Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
- Issue: Vol 52, No 4 (2018)
- Pages: 304-307
- Section: Article
- URL: https://journal-vniispk.ru/0091-150X/article/view/245148
- DOI: https://doi.org/10.1007/s11094-018-1811-8
- ID: 245148
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Abstract
2-Substituted 5-aryltetrazoles containing alkyl and aminoalkyl fragments were synthesized using alkylation and Mannich reactions. The tuberculostatic activity of the synthesized compounds against strain M. tuberculosis H37Rv was studied. Pronounced tuberculostatic activity (MIC ≤ 1.5 ìg/mL) was found for tetrazoles containing N(2) dimethyl- and diethylaminoethyl fragments.
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About the authors
R. I. Ishmetova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
Russian Federation, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
S. G. Tolshchina
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137
N. K. Ignatenko
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137
M. A. Kravchenko
Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, 50 XXIInd Parts”ezda St, Ekaterinburg, 620039
S. N. Skornyakov
Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, 50 XXIInd Parts”ezda St, Ekaterinburg, 620039
G. L. Rusinov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
Russian Federation, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
V. N. Charushin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
Russian Federation, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
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