Cytotoxic Copper(II) Complexes Based on 2,2'-Bipyridine/1,10-
Phenanthroline and 5-(4-Chlorophenyl)-1H-tetrazole:
Synthesis and Structures

Yu. A. Golubeva; Голубева Ю. А.; K. S. Smirnova; Смирнова К. С.; L. S. Klyushova; Клюшова Л. С.; A. S. Berezin; Березин А. С.; E. V. Lider; Лидер Е. В.

doi:10.31857/S0132344X2260062X

Cytotoxic Copper(II) Complexes Based on 2,2'-Bipyridine/1,10- Phenanthroline and 5-(4-Chlorophenyl)-1H-tetrazole: Synthesis and Structures

作者: Golubeva Y.A.¹, Smirnova K.S.¹, Klyushova L.S.², Berezin A.S.¹, Lider E.V.¹
隶属关系:
1. Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
2. Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia
期: 卷 49, 编号 9 (2023)
页面: 516-529
栏目: Articles
URL: https://journal-vniispk.ru/0132-344X/article/view/137305
DOI: https://doi.org/10.31857/S0132344X2260062X
EDN: https://elibrary.ru/WACYDM
ID: 137305

如何引用文章

全文:

开放存取

##reader.subscriptionAccessGranted##
受限制的访问

订阅存取

详细
作者简介
参考
补充文件
统计

详细

Five coordination compounds [Cu2(Bipy)2L4]·C2H5OH (Iа, Ib), [Cu2(Dmbipy)2L4] (II),
[Cu2(Phen)2L4]·H2O (IIIa), [Cu2(Dmphen)2L4] (IVa), and [Cu2(Phendione’)2L4]·2C2H5OH·2H2O (V) are
synthesized from 5-(4-chlorophenyl)-1H-tetrazole (HL), where Bipy is 2,2'-bipyridine, Dmbipy is 4,4'-
dimethyl-2,2'-bipyridine, Phen is 1,10-phenanthroline, Dmphen is 4,7-dimethyl-1,10-phenanthroline, and
Phendione’ is 6-ethoxy-6-hydroxy-1,10-phenanthrolin-5-one. The crystal structures of the complexes are
determined by X-ray diffraction (XRD) of single crystals (CIF files CCDC nos. 2225368 (Ia), 2225369 (Ib),
2225370 (II), 2225372 (IIIa), 2225373 (IVa), and 2225371 (V)). The compounds are binuclear due to the
bridging function of the tetrazolate anion, and the coordination number of copper is five in all synthesized
complexes. The cytotoxic activity of the complexes against the Hep2 and HepG2 cancer cell lines and noncancerous
human fibroblasts MRC-5 is studied. The complexes exhibit pronounced cytotoxic properties, and
compound V has the maximum selectivity index with respect to the cancer cells.

关键词

copper(II) complexes, 5-(4-chlorophenyl)-1H-tetrazole, 1,10-phenanthroline, XRD, cytotoxicity

参考

Rosenberg B., VanCamp L., Trosko J.E. et al. // Nature. 1969. V. 222. № 5191. P. 385.
Ferraro M.G., Piccolo M., Misso G. et al. // Pharmaceutics. 2022. V. 14. № 5. P. 954.
González-Ballesteros M.M., Mejía C., Ruiz-Azuara L. // FEBS Open Bio. 2022. V. 12. № 5. P. 880.
McGivern T.J.P., Afsharpour S., Marmion C.J. // Inorg. Chim. Acta. 2018. V. 472. P. 12.
Erxleben A. // Coord. Chem. Rev. 2018. V. 360. P. 92.
Molinaro C., Martoriati A., Pelinski L. et al. // Cancers. 2020. V. 12. № 10. P. 2863.
Kalinowski D.S., Stefani C., Toyokuni S. et al. // Biochim. Biophys. Acta, Mol. Cell Res. 2016. V. 1863. № 4. P. 727.
Jiang Y., Huo Z., Qi X. et al. // Nanomedicine. 2022. V. 17. № 5. P. 303.
Pinheiro A.C., Busatto F.F., Schaefer B.T. et al. // J. Inorg. Biochem. 2022. V. 237. P. 112013.
Dinev D., Popova K.B., Zhivkova T. et al. // Appl. Organomet. Chem. 2022. V. 36. № 10. P. e6862.
Cao H.Z., Yang W.T., Zheng P.S. // BMC Cancer. 2022. V. 22. № 1. P. 1.
Babahan-Bircan I., Emirdağ S., Özmen A. et al. // Appl. Organomet. Chem. 2022. V. 36. № 9. P. e6784.
Afroz L., Khan M.H.M., Vagdevi H.M. et al. // Emergent Mater. 2021. V. 5. № 4. P. 1133.
Khursheed S., Siddique H.R., Tabassum S. et al. // Dalton Trans. 2022. V. 51. № 31. P. 11713.
Santini C., Pellei M., Gandin V. et al. // Chem. Rev. 2013. V. 114. № 1. P. 815.
Krasnovskaya O., Naumov A., Guk D. et al. // Int. J. Mol. Sci. 2020. V. 21. P. 3965.
Vitomirov T., Dimiza F., Matić I.Z. et al. // J. Inorg. Biochem. 2022. V. 235. P. 111942.
Figueroa-Depaz Y., Pérez-Villanueva J., Soria-Arteche O. et al. // Molecules. 2022. V. 27. № 11. P. 3504.
Karpagam S., Mamindla A., Kumar Sali V. et al. // Inorg. Chim. Acta. 2022. V. 531. P. 120729.
Zehra S., Cirilli I., Silvestri S. et al. // Metallomics. 2021. V. 13. № 11. P. mfab064.
Zehra S., Gómez-Ruiz S., Siddique H.R. et al. // Dalton Trans. 2020. V. 49. № 46. P. 16830.
Paixão D.A., de Oliveira B.C.A., Almeida J.C. et al. // Inorg. Chim. Acta. 2020. V. 499. P. 119164.
Karpagam S., Kartikeyan R., Paravai N.P. et al. // J. Coord. Chem. 2019. V. 72. № 18. P. 3102.
Alvarez N., Mendes L.F.S., Kramer M.G. et al. // Inorg. Chim Acta. 2018. V. 483. P. 61.
Figueroa-DePaz Y., Resendiz-Acevedo K., Dávila-Manzanilla S.G. et al. // J. Inorg. Biochem. 2022. V. 231. P. 111772.
Kumari J., Mobin S.M., Mukhopadhyay S. et al. // Inorg. Chem. Commun. 2019. V. 105. P. 217.
Stoll S., Schweiger A. // J. Magn. Reson. 2006. V. 178. № 1. P. 42.
Bruker Apex3 Software Suite: Apex3, SADABS-2016/2 and SAINT. Version 2018.7-2. Madison (WI, USA): Bruker AXS Inc., 2017.
CrysAlisPro 1.171.38.46. The Woodlands (TX, USA), Rigaku Oxford Diffraction, 2015.
Sheldrick G.M. // Acta Crystallogr. A. 2015. V. 71. № 1. P. 3.
Sheldrick G.M. // Acta Crystallogr. C. 2015. V. 71. № 1. P. 3.
Dolomanov O.V., Bourhis L.J., Gildea R.J. et al. // J. Appl. Crystallogr. 2009. V. 42. № 2. P. 339.
Eremina J.A., Lider E.V., Samsonenko D.G. et al. // Inorg. Chim. Acta. 2019. V. 487. P. 138.
Smirnova K.S., Golubeva Y.A., Lider E.V. // Crystallogr. Rep. 2022. V. 67. № 4. P. 575.
Eremina J.A., Ermakova E.A., Smirnova K.S. et al. // Polyhedron. 2021. V. 206. P. 115352