Email this article Structural and thermodynamic parameters of a biopolymeric oral delivery system for liposomal form of a combination of nutraceuticals
- Authors: Semenova М.G.1, Antipova A.S.1, Martirosova E.I.1, Anokhina M.S.1, Zelikina D.V.1, Bogdanova N.G.1, Palmina N.P.1
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Affiliations:
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 43, No 11 (2024)
- Pages: 62-70
- Section: Chemical physics of biological processes
- URL: https://journal-vniispk.ru/0207-401X/article/view/281882
- DOI: https://doi.org/10.31857/S0207401X24110084
- ID: 281882
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Abstract
A liposomal form of a combination of hydrophobic nutraceuticals (omega-3 docosahexaenoic polyunsaturated fatty acid (DHA) and clove essential oil (CEО)) was prepared based on soya phosphatidylcholine (PC). The impact of DHA and CEO on the microviscosity of the bilayer of PC liposomes was investigated through the use of EPR spectroscopy. Furthermore, the influence of DHA and CEO on the phase state of the bilayer of model dipalmitoylphosphatidylcholine liposomes was ascertained through the analysis of DSC data. A combination of EPR spectroscopy, DSC and laser light scattering methods was employed to investigate the effect of liposome encapsulation (PC-DHA-CEO) with a covalent conjugate (С) of sodium caseinate and maltodextrin on the structural state of the encapsulated liposome. Furthermore, the investigation concentrated on the structural characteristics (molar mass, size, density, architecture and zeta potential) and the thermodynamic parameters (osmotic second virial coefficient) of the water-soluble supramolecular complex PC-DHA-CEO-С. The key structural parameters of this complex have been identified as providing effective protection of PUFAs included in its composition from oxidation by air oxygen.
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About the authors
М. G. Semenova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: mariagersem@mail.ru
Russian Federation, Moscow
A. S. Antipova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: mariagersem@mail.ru
Russian Federation, Moscow
E. I. Martirosova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: mariagersem@mail.ru
Russian Federation, Moscow
M. S. Anokhina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: mariagersem@mail.ru
Russian Federation, Moscow
D. V. Zelikina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: mariagersem@mail.ru
Russian Federation, Moscow
N. G. Bogdanova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: mariagersem@mail.ru
Russian Federation, Moscow
N. P. Palmina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: mariagersem@mail.ru
Russian Federation, Moscow
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