Comparative effectiveness of diosmin and hesperidin combination in patients with chronic venous insufficiency
- Autores: Kseneva S.1, Trifonova O.1, Zolotarev A.1, Pikhtunova E.1, Udut V.1
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Afiliações:
- Tomsk National Research Medical Centre of the Russian Academy of Sciences
- Edição: Volume 36, Nº 6 (2025)
- Páginas: 27-30
- Seção: Pharmacology
- URL: https://journal-vniispk.ru/0236-3054/article/view/310681
- DOI: https://doi.org/10.29296/25877305-2025-06-05
- ID: 310681
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Resumo
Objective. Comparative analysis of the therapeutic efficacy of the combined preparation of diosmin and hesperidin in two cohorts of patients with chronic venous insufficiency (CVI) stratified by body mass index.
Material and methods. A prospective clinically controlled study of the efficacy of therapy with the combination of diosmin and hesperidin in 104 patients with chronic venous diseases (C0-C3 according to CEAR) was carried out. The efficacy of pharmacotherapy was assessed by comparative analysis between the group of patients with excessive body weight and the group with normal anthropometric indices.
Results. After 8 weeks of treatment with the combination of diosmin and hesperidin a significant decrease in the severity of discomfort in the lower extremities, intensity of heaviness, leg pain and the feeling of leg oedema was observed (p<0,01). The effect of the therapy in both groups was a decrease in the volume of the lower leg and improvement of the CIVIQ-20 quality of life scores (p<0.01).
Conclusion. The obtained data indicate comparable high efficacy of the combination of diosmin and hesperidin for treatment of clinical manifestations of CVI in patients with both normal and overweight.
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##article.viewOnOriginalSite##Sobre autores
S. Kseneva
Tomsk National Research Medical Centre of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: zolotarevf_aleksey@inbox.ru
ORCID ID: 0000-0002-5448-3752
Código SPIN: 8644-9420
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, MD
Rússia, TomskO. Trifonova
Tomsk National Research Medical Centre of the Russian Academy of Sciences
Email: zolotarevf_aleksey@inbox.ru
ORCID ID: 0000-0001-9425-5765
Código SPIN: 6839-7035
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, MD
Rússia, TomskA. Zolotarev
Tomsk National Research Medical Centre of the Russian Academy of Sciences
Email: zolotarevf_aleksey@inbox.ru
ORCID ID: 0009-0004-8878-9524
Código SPIN: 2993-9722
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Rússia, TomskE. Pikhtunova
Tomsk National Research Medical Centre of the Russian Academy of Sciences
Email: zolotarevf_aleksey@inbox.ru
ORCID ID: 0009-0003-8741-0722
Código SPIN: 5958-3183
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Rússia, TomskV. Udut
Tomsk National Research Medical Centre of the Russian Academy of Sciences
Email: zolotarevf_aleksey@inbox.ru
ORCID ID: 0000-0002-3829-7132
Código SPIN: 8645-9815
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Corresponding member of the Russian Academy of Sciences, MD
Rússia, TomskBibliografia
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