Markers of hepatitis E among the population of the Greater Sochi and in monkeys of the Adler primate center
- Authors: Korzaia L.I.1, Keburia V.V.1, Dogadov D.I.1, Lapin B.A.1, Kyuregyan K.K.2, Mikhailov M.I.2
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Affiliations:
- Research Institute of Medical Primatology
- Chumakov Institute of Poliomyelitis and Viral Encephalitides
- Issue: Vol 61, No 4 (2016)
- Pages: 176-180
- Section: ORIGINAL RESEARCHES
- URL: https://journal-vniispk.ru/0507-4088/article/view/117894
- DOI: https://doi.org/10.18821/0507-4088-2016-61-4-176-180
- ID: 117894
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Full Text
Abstract
Serum from humans (n = 646) and monkeys (n = 1867) collected during the period 1999-2013 was tested by enzyme immunoassay. Anti-HEV IgG was detected significantly more frequently (P ≥ 0.001) in rhesus macaques (Macaca mulatta) - 45.1 ± 1.6% (n = 1001) than in cynomolgus macaques (M. fascicularis) 16.2 ± 1.8% (n = 426). Single seropositive individuals were found among M. nemestrina - 4.0±2.8% (n = 50). Anti-HEV was not detected in the sera of green monkeys (Chlorocebus aethiops) - n = 162, Papio hamadryas (n = 124), and Papio anubis - n = 104. The presence of the anti-HEV IgM indicating the cases of fresh infection in Macaca mulatta - 2.1 ± 0.5% (n = 717) and M. fascicularis - 3.5 ± 1.3% (n = 266) is of great significance. The overall frequency of detection of the anti-HEV IgG among the staff of the Adler Primate Center - 6.8 ± 2.3% (n = 118) was significantly lower (P ≤ 0.001) than among the population of the Greater Sochi - 15.9% ± 1.6 (n = 528). It is important that only in patients of medical institutions (clinic, hospital, cancer center), anti-HEV IgM were detected (2.7-11.8%) along with anti-HEV IgG (15-23.5%), thereby indicating the presence of acute cases of HEV infection among this population. HEV RNA was not detected in the serum of anti-HEV IgM-positive people and monkeys. Seroepidemiological data do not confirm the assumption on the ability of seropositive monkeys of Macaca genus to be a natural reservoir of HEV infection for humans.
Keywords
About the authors
L. I. Korzaia
Research Institute of Medical Primatology
Author for correspondence.
Email: likorzaya@rambler.ru
Russian Federation
V. V. Keburia
Research Institute of Medical PrimatologyRussian Federation
D. I. Dogadov
Research Institute of Medical PrimatologyRussian Federation
B. A. Lapin
Research Institute of Medical PrimatologyRussian Federation
K. K. Kyuregyan
Chumakov Institute of Poliomyelitis and Viral EncephalitidesRussian Federation
M. I. Mikhailov
Chumakov Institute of Poliomyelitis and Viral EncephalitidesRussian Federation
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