Parameters of the CD4-Cell count and viral load in human immunodeficiency virus type 1 (HIV-1) infected patients
- Authors: Selimova L.М.1,2, Serebrovskaya L.V.1,2, Ivanova L.А.2, Kravchenko А.V.2, Buravtsova Е.V.2
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Affiliations:
- “The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation
- Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
- Issue: Vol 60, No 2 (2015)
- Pages: 31-34
- Section: ORIGINAL RESEARCH
- URL: https://journal-vniispk.ru/0507-4088/article/view/118073
- ID: 118073
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Full Text
Abstract
In this work the specific features of parameters of plasma CD4 T-lymphocytes count and level virus RNA in the HIV-infected patients were studied. 22% correlation between reduction of CD4 cell count and an increase in virus RNA level was observed in persons that did not receive antiretroviral treatment during the third HIV- infection phase. During this phase of infection patients exhibited a growth of the median value of virus load in cases of both rise as decline in CD4 cell count during long observation period. In addition, towards the end of the observation period, the percentage of patients with virus load >3.3 lg copies/ml considerably expanded. 43% correlation between CD4 cell count and duration of the HIV-infection was detected during the fourth infection phase in persons that did not receive antiretroviral treatment. Most of the patients in the third and the fourth infection phases had essential CD4 cell count growth during antiretroviral treatment. Best values were observed in patients with the initial value of CD4 >400 cells/pl belonging to the third HIV-infection phase.
About the authors
L. М. Selimova
“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation; Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
Author for correspondence.
Email: lselim@mail.ru
Lyudmila Selimova, Doctor of Biological Sciences
123098, Moscow
105275, Moscow
Russian FederationL. V. Serebrovskaya
“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation; Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
Email: fake@neicon.ru
123098, Moscow
105275, Moscow
Russian FederationL. А. Ivanova
Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
Email: fake@neicon.ru
105275, Moscow Russian Federation
А. V. Kravchenko
Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
Email: fake@neicon.ru
105275, Moscow Russian Federation
Е. V. Buravtsova
Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
Email: fake@neicon.ru
105275, Moscow Russian Federation
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