Rapid spread of the HIV-1 circular recombinant CRF02-AG in Russia and neighboring countries

F. F. Moskaleychik; Москалейчик Ф. Ф.; V. Yu. Laga; Лага В. Ю.; E. Delgado; Дельгадо Е.; Y. Vega; Вега И.; A. Fernandez-Garcia; Фернандес-Гарсия А.; L. Perez-Alvarez; Перес-Альварес Л.; G. V. Kornilaeva; Корнилаева Г. В.; A. Yu. Pronin; Пронин А. Ю.; Yu. V. Zhernov; Жернов Ю. В.; M. M. Thomson; Томсон М. М.; M. R. Bobkova; Бобкова М. Р.; E. V. Karamov; Карамов Э. В.

Rapid spread of the HIV-1 circular recombinant CRF02-AG in Russia and neighboring countries

作者: Moskaleychik F.F.¹, Laga V.Y.¹, Delgado E.², Vega Y.², Fernandez-Garcia A.², Perez-Alvarez L.², Kornilaeva G.V.¹, Pronin A.Y.³, Zhernov Y.V.¹, Thomson M.M.², Bobkova M.R.¹, Karamov E.V.¹
隶属关系:
1. “The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation
2. Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda
3. AIDS Center of Moscow Region
期: 卷 60, 编号 6 (2015)
页面: 14-19
栏目: ORIGINAL RESEARCH
URL: https://journal-vniispk.ru/0507-4088/article/view/118109
ID: 118109

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The spread of the HIV-1 circular recombinant CRF02-AG in countries of the former Soviet Union (Commonwealth of Independent States, CIS ) was studied using partial and full-genome sequences. The full-genome sequence of the CRF02-AG recombinant circulating in Russia was obtained for the first time. A global phylogenetic tree of CRF02-AG full-genome sequences was constructed. Three distinct groups of the sequences were detected as clustered by the geographical location (CIS, South Korea, and France), which is indicative of the single-virus introduction in each of the regions mentioned above. The CIS cluster exhibiting minimum genetic diversity was, therefore, relatively young. The phylogenetic analysis of the env gene sequences within the CIS cluster made it possible to clearly discriminate three branches: two of Russian and one of Uzbek origin. The low genetic diversity within the two Russian subclusters provides evidence of at least two recent independent introductions of the CRF02-AG recombinant from Central Asia into Russia.

关键词

HIV, subtype, circular recombinant form, molecular epidemiology, phylogenetic tree

作者简介

F. Moskaleychik

“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: fedor.mosckaleychick@gmail.com

Fedor Moskaleychik, MD,PhD

123098, Moscow

俄罗斯联邦

参考

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Rapid spread of the HIV-1 circular recombinant CRF02-AG in Russia and neighboring countries

全文:

详细

关键词

作者简介

F. Moskaleychik

V. Laga

E. Delgado

Y. Vega

A. Fernandez-Garcia

L. Perez-Alvarez

G. Kornilaeva

A. Pronin

Yu. Zhernov

M. Thomson

M. Bobkova

E. Karamov

参考

补充文件