Distribution of human gene polymorphisms allele frequencies associated with viral infections
- 作者: Vlasenko N.V.1, Chanyshev M.D.2, Dubodelov D.V.1, Serkov A.A.1, Solopova G.G.3, Sacuk A.V.3, Snicar A.V.4, Semenenko T.А.5, Kuzin S.N.1, Akimkin V.G.1
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隶属关系:
- Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
- Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology
- Demikhov Moscow City Clinical Hospital
- N.F. Gamaleya National Research Center of Epidemiology and Microbiology
- 期: 卷 68, 编号 5 (2023)
- 页面: 404-414
- 栏目: ORIGINAL RESEARCH
- URL: https://journal-vniispk.ru/0507-4088/article/view/231859
- DOI: https://doi.org/10.36233/0507-4088-189
- EDN: https://elibrary.ru/bguoyy
- ID: 231859
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Introduction. The design of studies aimed at finding the association between the genetic factor and the studied feature (disease) involves a comparison of the ratio of genotypes or allelic proportions in the study group with those in the control group. At the stage of determining the ratio of genotypes of the studied polymorphisms in the reference group, researchers meet a number of problems, which are the subject of the present work.
Aim of the work is to provide scientific rationale for the feasibility of creating a national information system comprising genetic data of the relatively healthy population of Russia, incorporating its ethnic diversity.
Materials and methods. The study group, total 1020 people, was genotyped for a number of single nucleotide polymorphisms of human genes. A comparative characteristic of the frequency distribution of the studied polymorphisms with those presented in international databases as reference data was carried out using χ2 index.
Results. The frequency of SNP rs4986790 of the TLR4 gene significantly differs from the EUR population (p = 0.032) and the CEU subpopulation (p = 0.047). The allele frequencies of the rs1800795 (IL6) and rs1800896 (IL10) polymorphisms in the study population differ from the CEU subgroup (p = 0.030 and 0.012, respectively). The frequency of SNP rs2295119 (HLA-DPA2) in the study group is significantly different from the EUR population (p = 0.034).
Conclusion. The analysis carried out in this work confirms the need to create a domestic information system containing data on the occurrence of SNP alleles and genotypes for a conditionally healthy population and in subgroups with various pathological conditions.
作者简介
Natalia Vlasenko
Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
编辑信件的主要联系方式.
Email: nvzuz@mail.ru
ORCID iD: 0000-0002-2388-1483
Researcher, Laboratory of viral hepatitis
俄罗斯联邦, 111123, MoscowMikhail Chanyshev
Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: chanish@mail.ru
ORCID iD: 0000-0002-6943-2915
Researcher, Laboratory of genomic research
俄罗斯联邦, 111123, MoscowDmitriy Dubodelov
Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: gradient27@mail.ru
ORCID iD: 0000-0003-3093-5731
Cand. Sci. (Med.), senior researcher, Laboratory of viral hepatitis
俄罗斯联邦, 111123, MoscowArtem Serkov
Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: toms8191@mail.ru
ORCID iD: 0009-0006-4086-8324
Research laboratory assistant, Laboratory of viral hepatitis
俄罗斯联邦, 111123, MoscowGalina Solopova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology
Email: galina.solopova@fnkc.ru
ORCID iD: 0000-0002-1680-7269
PhD, Deputy Chief Physician for Infection Control
俄罗斯联邦, 117997, MoscowAnastasija Sacuk
Dmitry Rogachev National Medical Research Center of Pediatric Hematology
Email: vnpoemp@yandex.ru
ORCID iD: 0000-0003-3293-2008
PhD, epidemiologist
俄罗斯联邦, 117997, MoscowArtem Snicar
Demikhov Moscow City Clinical Hospital
Email: snitsarav@yandex.ru
ORCID iD: 0000-0001-6053-4651
Deputy Chief Medical Officer
俄罗斯联邦, 109263, MoscowTatiana Semenenko
N.F. Gamaleya National Research Center of Epidemiology and Microbiology
Email: semenenko@gamaleya.org
ORCID iD: 0000-0002-6686-9011
D. Sci. (Med.), Professor, Head of the Epidemiology Department
俄罗斯联邦, 123098, MoscowStanislav Kuzin
Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: drkuzin@list.ru
ORCID iD: 0000-0002-0616-9777
D. Sci. (Med.), Professor, Head, Laboratory of viral hepatitis
俄罗斯联邦, 111123, MoscowVasily Akimkin
Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: crie@pcr.ru
ORCID iD: 0000-0003-4228-9044
D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director
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