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Application of the ANRORC-Process for the Directional Synthesis of 5-Ureido-2-Pyrazolines as a Biologically Active Co-Ligand of Gold Glyconanoparticles
- Authors: Ershov A.Y.1, Martynenkov A.A.1, Lagoda I.V.2, Batyrenko A.A.2
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Affiliations:
- Institute of Macromolecular Compounds of the Russian Academy of Sciences
- State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Issue: Vol 60, No 10 (2024)
- Pages: 1078-1081
- Section: Articles
- URL: https://journal-vniispk.ru/0514-7492/article/view/283230
- DOI: https://doi.org/10.31857/S0514749224100112
- EDN: https://elibrary.ru/QKYXDQ
- ID: 283230
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Abstract
Interaction of 1-phenyl-4,6-dimethylpyrimidine-2(1H)-one with 4-mercaptobuturic acid hydrazide proceeds as ANRORC (Addition of the Nucleophile–Ring Opening–Ring Closure) process and gives in the formation with 60% yield of 1-(4-mercaptobutanoyl)-3,5-dimethyl-5-(3-phenylcarbamoylamino)-2-pyrazoline as promising сo-ligand for the preparation of gold glyconanoparticles for biomedical purposes.
Keywords
About the authors
A. Y. Ershov
Institute of Macromolecular Compounds of the Russian Academy of Sciences
Email: martynenkoff@gmail.com
ORCID iD: 0000-0002-2266-4380
Russian Federation, Bol′shoi prosp., 31, St. Petersburg, 199004
A. A. Martynenkov
Institute of Macromolecular Compounds of the Russian Academy of Sciences
Author for correspondence.
Email: martynenkoff@gmail.com
ORCID iD: 0000-0002-0951-1451
Russian Federation, Bol′shoi prosp., 31, St. Petersburg, 199004
I. V. Lagoda
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: martynenkoff@gmail.com
ORCID iD: 0000-0002-3906-2909
Russian Federation, Lesoparkovaya ul., 4, St. Petersburg, 195043
A. A. Batyrenko
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: martynenkoff@gmail.com
ORCID iD: 0000-0001-9688-3650
Russian Federation, Lesoparkovaya ul., 4, St. Petersburg, 195043
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