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Synthesis of Ethyl Ester of 11-Deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B1_Analog of Misoprostol
- Authors: Ivanova N.A.1, Shavaleeva G.A.1, Spirikhin L.V.1, Miftakhov M.S.1
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Affiliations:
- Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UIC UFRC RAS)
- Issue: Vol 60, No 9 (2024)
- Pages: 967-972
- Section: Articles
- URL: https://journal-vniispk.ru/0514-7492/article/view/284752
- DOI: https://doi.org/10.31857/S0514749224090034
- EDN: https://elibrary.ru/QNXXPI
- ID: 284752
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Abstract
By 1,2-addition to the keto group ethyl-(5-oxocyclopent-1-enyl)heptenoate lithium acetylenide from 4-hydroxy-4,5-dimethylheptin-1, followed by oxidative isomerization of the resulting adduct with PCC was obtained ethyl ester 11-deoxy-13,14-didehydro-17-methyl-20-nor-prostaglandin B1.
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About the authors
N. A. Ivanova
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UIC UFRC RAS)
Author for correspondence.
Email: gushavaleeva@mail.ru
ORCID iD: 0000-0002-3101-1285
Russian Federation, prosp. Oktabrya, 71, Ufa, 450054
G. A. Shavaleeva
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UIC UFRC RAS)
Email: gushavaleeva@mail.ru
ORCID iD: 0000-0003-1345-9139
Russian Federation, prosp. Oktabrya, 71, Ufa, 450054
L. V. Spirikhin
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UIC UFRC RAS)
Email: gushavaleeva@mail.ru
ORCID iD: 0000-0002-3163-882X
Russian Federation, prosp. Oktabrya, 71, Ufa, 450054
M. S. Miftakhov
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UIC UFRC RAS)
Email: gushavaleeva@mail.ru
ORCID iD: 0000-0002-0269-7484
Russian Federation, prosp. Oktabrya, 71, Ufa, 450054
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