Email this article New chemical transformation of substituted dinitroacetonitrilе in the reaction with isoquinoline in presence of dimethylbut-2-indioate
- Authors: Tyrkov A.G.1, Yurtaeva E.A.2
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Affiliations:
- Astrakhan Tatishchev State University
- Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University
- Issue: Vol 61, No 2 (2025)
- Pages: 203-207
- Section: Articles
- URL: https://journal-vniispk.ru/0514-7492/article/view/304565
- DOI: https://doi.org/10.31857/S0514749225020115
- EDN: https://elibrary.ru/dhgics
- ID: 304565
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Abstract
The reaction of substituted dinitroacetonitrile with isoquinoline in the presence of dimethylbut-2-indioate results in the formation of 1,3-dipolar cycloaddition products – a mixture of diastereomeric dimethyl-2-dinitromethyl-1,1bH-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates. The obtained compounds can be considered as promising synthons with potential antituberculosis and fungicidal activity.
About the authors
A. G. Tyrkov
Astrakhan Tatishchev State University
Email: tyrkov@rambler.ru
pl. Shaumyana, 1, Astrakhan, 414000 Russia
E. A. Yurtaeva
Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical Universityprosp. Kalinina, 11, Pyatigorsk, 357532 Russia
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