Synthesis of New Condensed Derivatives of Thieno[3,2- d ]-pyrimidines Based on 7,7-Dimethyl-2-mercapto-4-(2-furyl)-3-cyano-7,8-dihydro-5 H -pyrano[4,3- b ]pyridine

V. V. Dabaeva; Дабаева В. В.; I. M. Barkhudaryants; Бархударянц И. М.; E. G. Paronikyan; Пароникян Е. Г.; Sh. Sh. Dashyan; Дашян Ш. Ш.; M. R. Baghdasaryan; Багдасарян М. Р.

doi:10.31857/S0514749225010086

Synthesis of New Condensed Derivatives of Thieno[3,2-d]-pyrimidines Based on 7,7-Dimethyl-2-mercapto-4-(2-furyl)-3-cyano-7,8-dihydro-5H-pyrano[4,3-b]pyridine

Авторлар: Dabaeva V.V.¹, Barkhudaryants I.M.¹, Paronikyan E.G.¹, Dashyan S.S.¹, Baghdasaryan M.R.¹
Мекемелер:
1. Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Шығарылым: Том 61, № 1 (2025)
Беттер: 102-108
Бөлім: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
URL: https://journal-vniispk.ru/0514-7492/article/view/291951
DOI: https://doi.org/10.31857/S0514749225010086
EDN: https://elibrary.ru/AFKMTG
ID: 291951

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Аннотация

Methods for the synthesis of new condensed thieno[3,2-e]pyridines and thieno[3,2-d]pyrimidines have been developed. The reaction of 7,7-dimethyl-2-mercapto-4-(2-furyl)-3-cyano-7,8-dihydro-5H-pyrano[4,3-b]pyridine with chloroacetic acid amides has been established depending on temperature. It has been shown that at high temperatures alkylation and intramolecular cyclization (one pot reaction) occur with the formation of pyrano[4,3-b]thieno[3,2-e]pyridines. New derivatives of condensed tetracyclic thieno[3,2-d]pyrimidines were synthesized by condensation of pyrano[4,3-b]thieno[3,2-e]pyridine carboxamides with orthoformic acid triethyl ester.

Негізгі сөздер

alkylation, one pot reaction, thieno[3,2-е]pyridine, thieno[3,2-d]pyrimidine

Толық мәтін

Әдебиет тізімі

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