Synthesis of New Condensed Derivatives of Thieno[3,2- d ]-pyrimidines Based on 7,7-Dimethyl-2-mercapto-4-(2-furyl)-3-cyano-7,8-dihydro-5 H -pyrano[4,3- b ]pyridine

V. V. Dabaeva; Дабаева В. В.; I. M. Barkhudaryants; Бархударянц И. М.; E. G. Paronikyan; Пароникян Е. Г.; Sh. Sh. Dashyan; Дашян Ш. Ш.; M. R. Baghdasaryan; Багдасарян М. Р.

doi:10.31857/S0514749225010086

Synthesis of New Condensed Derivatives of Thieno[3,2-d]-pyrimidines Based on 7,7-Dimethyl-2-mercapto-4-(2-furyl)-3-cyano-7,8-dihydro-5H-pyrano[4,3-b]pyridine

Authors: Dabaeva V.V.¹, Barkhudaryants I.M.¹, Paronikyan E.G.¹, Dashyan S.S.¹, Baghdasaryan M.R.¹
Affiliations:
1. Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Issue: Vol 61, No 1 (2025)
Pages: 102-108
Section: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
URL: https://journal-vniispk.ru/0514-7492/article/view/291951
DOI: https://doi.org/10.31857/S0514749225010086
EDN: https://elibrary.ru/AFKMTG
ID: 291951

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Abstract

Methods for the synthesis of new condensed thieno[3,2-e]pyridines and thieno[3,2-d]pyrimidines have been developed. The reaction of 7,7-dimethyl-2-mercapto-4-(2-furyl)-3-cyano-7,8-dihydro-5H-pyrano[4,3-b]pyridine with chloroacetic acid amides has been established depending on temperature. It has been shown that at high temperatures alkylation and intramolecular cyclization (one pot reaction) occur with the formation of pyrano[4,3-b]thieno[3,2-e]pyridines. New derivatives of condensed tetracyclic thieno[3,2-d]pyrimidines were synthesized by condensation of pyrano[4,3-b]thieno[3,2-e]pyridine carboxamides with orthoformic acid triethyl ester.

Keywords

alkylation, one pot reaction, thieno[3,2-е]pyridine, thieno[3,2-d]pyrimidine

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