Membranotropic Property and Antibiofilm Efficacy of Novel Phosphonium Derivatives Bearing Phenolic Moiety

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

New derivatives of phosphonium salts (Z)-(2-(2-hydroxy-5-chlorphenyl)-2-phenylethenyl)octyldiphenyl-phosphonium chloride (PP8) and (2-hydroxybenzyl)dodecyldiphenylphosphonium chloride (6.5) were found to cause depolarization and permeabilization of the bacterial membrane. The ability of phosphonium salts to prevent the formation of Staphylococcus aureus biofilms and to disrupt them was demonstrated. Furthermore, the results demonstrated that the substances do not cause resistance development in the S. aureus strain. Finally, compound PP8 did not demonstrate mutagenic properties in the Ames test using strains of Salmonella typhimurium TA100 and S. typhimurium TA98.

Авторлар туралы

A. Lyubina

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

A. Voloshina

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

S. Amerkhanova

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

A. Sapunova

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

D. Tatarinov

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

V. Mironov

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: aplyubina@gmail.com
Kazan, 420088 Russia

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