Role of cholino- and adrenoblockers in the development of stimulatory reactions in the ascending colon, which are caused by the administration of serotonin adipinate

The involvement of adren- and cholinergic mechanisms in the stimulatory effect of exogenous serotonin on the motility of the ascending colon was defined. Acute experiments were carried out on rats under surgical anesthesia, mechanical ventilation, bilateral vagotomy, and bilateral glossopharyngeal nerve ligation. The mechanical activity of the ascending colon in response to the administration of serotonin adipinate and continuous exposure to adreno- and cholinoblockers was recorded in intact animals. Adreno- and cholinoreceptor blockade was found not only to prevent, but also to promote the manifestation of ascending colon reactions to serotonin; moreover, N-cholinoreceptor blockade increased the magnitude of stimulatory effects of the colon by more than 4 times. It was concluded that adren- and cholinergic mechanisms impeded the occurrence of stimulatory reactions of serotonin-reactive structures to colonic motility.

serotonin-reactive structures, serotonin, ascending colon, adrenoreceptors, cholinoreceptors