Email this article The effectiveness and safety of pharmacotherapy against the background of application of Gliquidone
- Authors: Titov D.S.1, Pravkin S.K1
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Affiliations:
- The academician I.P. Pavlov Ryazanskiy state medical university
- Issue: Vol 22, No 4 (2016)
- Pages: 203-206
- Section: Articles
- URL: https://journal-vniispk.ru/0869-2106/article/view/38358
- DOI: https://doi.org/10.18821/0869-2106-2016-22-4-203-206
- ID: 38358
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Abstract
The study was carried out to investigate using rabbits in vivo effect of Gliquidone on functional activity of protein-carrier of glycoprotein-P (P-gp, ABCB1-protein). The activity of P-gp was evaluated according pharmacokinetics of its marker substrate - Fexofenadine after single endogastric introduction. The application of Gliquidone in dosage of 10 mg per 1 kg of body mass during 14 days resulted in no alteration of concentration of Fexofenadine, period of its partial ejection, area under pharmacokinetic curve “concentration-time” from zero to last point of blood sampling, area under pharmacokinetic curve “concentration-time” from zero to infinity and also time of holding of marker substrate, total clearance and absorption coefficient. All this testifies absence of effect of Gliquidone on functional activity of protein-carrier at the level of integral organism. No alterations of pharmacokinetic parameters of Fexofenadine at the 5th day of cessation of Gliquidone were observed.
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##article.viewOnOriginalSite##About the authors
Dmitriy S. Titov
The academician I.P. Pavlov Ryazanskiy state medical university
Email: i3762@yandex.ru
post-graduate student of chair of pharmacology with course of pharmacy 390026, Ryazan, Russia
S. K Pravkin
The academician I.P. Pavlov Ryazanskiy state medical university390026, Ryazan, Russia
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