Growth patterns in children with cerebral palsy and the range of treatments provided: a cross-sectional study of data from five rehabilitation centers
- Authors: Tomov A.D.1, Babaitsev A.V.2, Kadyrova M.A.3,4, Larkin V.S.3,4, Lepshokov Y.S.5, Ryabokon A.M.6, Prokhorov V.V.7, Popkov D.A.1,2,8
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Affiliations:
- Priorov National Medical Research Center for Traumatology and Orthopedics
- Orthopaedic Clinic “ORTO-Prostranstvo”
- Togliatti City Children’s Hospital № 1
- Orthopaedic Centre “First Ray”
- Rehabilitation Centre “Physio Kids”
- Orthopaedic Cabinet “Way to Dream”
- Centre of Adaptive Physical Culture for Persons with Physical Disabilities
- National Medical Research Centre of Traumatology and Orthopaedics named after Academician G.A. Ilizarov
- Issue: Vol 32, No 1 (2025)
- Pages: 35-43
- Section: Original study articles
- URL: https://journal-vniispk.ru/0869-8678/article/view/290965
- DOI: https://doi.org/10.17816/vto626900
- ID: 290965
Cite item
Abstract
BACKGROUND: Measurement and evaluation of anthropometric data of children with cerebral palsy are essential for the development of national patient registers. Studies of the patients' anthropometric parameters observed in rehabilitation centres make it possible to form a broad sample for research.
AIM: To study the growth patterns of children with cerebral palsy depending on the degree of impairment of global motor functions, age, and gender; to compare the developmental patterns with published reference data of children with cerebral palsy; to evaluate the range of treatment used and the frequency of its elements in children treated and monitored in rehabilitation centres who participated in the study.
MATERIALS AND METHODS: In a prospective study, measurements were collected through 2023 at five rehabilitation centers. 178 patients met inclusion criteria. The parameters of height, weight, BMI and their deviations from reference data for children with cerebral palsy were studied. The range of treatments provided in addition to physical rehabilitation was examined.
RESULTS: We found a significant difference in height indices (z-score values were higher than 0.7) compared to previously proposed North American reference anthropometric data for children with cerebral palsy. In our cohort, the increase in height score was independent of age, sex and GMFCS level. On the other hand, the concordance of weight and BMI was close to the reference charts. We believe that in order to monitor the development of children with cerebral palsy, it is necessary to create our own database of anthropometric data, calculating charts and percentiles of development.
CONCLUSION: The strategy for future research should also focus on the creation of regional registries of patients with cerebral palsy, which are necessary for multifactorial analysis taking into account epigenetic factors. In our sample of patients, the range and choice of treatments can be considered quite satisfactory — the frequency of orthopaedic surgery for secondary orthopaedic complications is around 40% of cases.
Full Text
##article.viewOnOriginalSite##About the authors
Akhmed D. Tomov
Priorov National Medical Research Center for Traumatology and Orthopedics
Author for correspondence.
Email: doc0645@mail.ru
ORCID iD: 0009-0001-2981-7722
SPIN-code: 2949-6153
MD, MD, Cand. Sci. (Medicine)
Russian Federation, 10 Priorova str., 127299 MoscowArtem V. Babaitsev
Orthopaedic Clinic “ORTO-Prostranstvo”
Email: yetik530mnm@gmail.com
MD
Russian Federation, MoscowMaria A. Kadyrova
Togliatti City Children’s Hospital № 1; Orthopaedic Centre “First Ray”
Email: kadirof-m@live.ru
MD
Russian Federation, Togliatti; TogliattiViktor S. Larkin
Togliatti City Children’s Hospital № 1; Orthopaedic Centre “First Ray”
Email: v.larkin63@yandex.ru
ORCID iD: 0009-0003-9058-4029
Russian Federation, Togliatti; Togliatti
Yanis S. Lepshokov
Rehabilitation Centre “Physio Kids”
Email: yanis_0990@mail.ru
MD
Russian Federation, CherkesskAleksandr M. Ryabokon
Orthopaedic Cabinet “Way to Dream”
Email: ryabokon9995@gmail.com
MD
Russian Federation, MoscowVahtang V. Prokhorov
Centre of Adaptive Physical Culture for Persons with Physical Disabilities
Email: dcp.centr@yandex.ru
MD
Russian Federation, MoscowDmitrii A. Popkov
Priorov National Medical Research Center for Traumatology and Orthopedics; Orthopaedic Clinic “ORTO-Prostranstvo”; National Medical Research Centre of Traumatology and Orthopaedics named after Academician G.A. Ilizarov
Email: dpopkov@mail.ru
ORCID iD: 0000-0002-8996-867X
SPIN-code: 6387-0545
MD, Dr. Sci. (Medicine), professor of the Russian Academy of Sciences
Russian Federation, 10 Priorova str., 127299 Moscow; Moscow; KurganReferences
- Van den Broeck J, Willie D, Younger N. The World Health Organization child growth standards: expected implications for clinical and epidemiological research. Eur J Pediatr. 2009;168(2):247–251. doi: 10.1007/s00431-008-0796-9
- Stevenson RD, Conaway M, Chumlea WC, et al.; North American Growth in Cerebral Palsy Study. Growth and health in children with moderate-to-severe cerebral palsy. Pediatrics. 2006;118(3):1010–1018. doi: 10.1542/peds.2006-0298
- Day SM, Strauss DJ, Vachon PJ, et al. Growth patterns in a population of children and adolescents with cerebral palsy. Dev Med Child Neurol. 2007;49(3):167–171. doi: 10.1111/j.1469-8749.2007.00167.x
- Stevenson RD, Roberts CD, Vogtle L. The effects of non-nutritional factors on growth in cerebral palsy. Dev Med Child Neurol. 1995;37(2):124–130. doi: 10.1111/j.1469-8749.1995.tb11981.x
- Oftedal S, Davies PS, Boyd RN, et al. Longitudinal Growth, Diet, and Physical Activity in Young Children With Cerebral Palsy. Pediatrics. 2016;138(4):e20161321. doi: 10.1542/peds.2016-1321
- Kuperminc MN, Gurka MJ, Houlihan CM, et al. Puberty, statural growth, and growth hormone release in children with cerebral palsy. J Pediatr Rehabil Med. 2009;2(2):131–141. doi: 10.3233/PRM-2009-0072
- Brooks J, Day S, Shavelle R, Strauss D. Low weight, morbidity, and mortality in children with cerebral palsy: new clinical growth charts. Pediatrics. 2011;128(2):e299–307.
- Araújo LA, Silva LR. Anthropometric assessment of patients with cerebral palsy: which curves are more appropriate? J Pediatr (Rio J). 2013;89(3):307–314. doi: 10.1016/j.jped.2012.11.008
- Wright CM, Reynolds L, Ingram E, Cole TJ, Brooks J. Validation of US cerebral palsy growth charts using a UK cohort. Dev Med Child Neurol. 2017;59(9):933–938. doi: 10.1111/dmcn.13495
- Graham HK, Rosenbaum P, Paneth N, et al. Cerebral palsy. Nat Rev Dis Primers. 2016;2:15082. doi: 10.1038/nrdp.2015.82
- Multani I, Manji J, Hastings-Ison T, Khot A, Graham K. Botulinum Toxin in the Management of Children with Cerebral Palsy. Paediatr Drugs. 2019;21(4):261–281. doi: 10.1007/s40272-019-00344-8
- Graham D, Aquilina K, Cawker S, Paget S, Wimalasundera N. Single-level selective dorsal rhizotomy for spastic cerebral palsy. J Spine Surg. 2016;2(3):195–201. doi: 10.21037/jss.2016.08.08
- Vetrile MS, Kuleshov AA, Makarov SN, et al. Features of vertebral-pelvic fixation in case of deformities and traumatic injuries of the spine. N.N. Priorov Journal of Traumatology and Orthopedics. 2021;28(1):17–27. (In Russ.) doi: 10.17816/vto63954
- Surveillance of Cerebral Palsy in Europe. Surveillance of cerebral palsy in Europe: a collaboration of cerebral palsy surveys and registers. Surveillance of Cerebral Palsy in Europe (SCPE). Dev Med Child Neurol. 2000;42(12):816–824. doi: 10.1017/s0012162200001511
- Rosenbaum P, Paneth N, Leviton A, et al. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl. 2007;109:8–14. Erratum in: Dev Med Child Neurol. 2007;49(6):480.
- Wood E, Rosenbaum P. The gross motor function classification system for cerebral palsy: a study of reliability and stability over time. Dev Med Child Neurol. 2000;42(5):292–296. doi: 10.1017/s0012162200000529
- Levin D, Marryat L, Cole TJ, et al. Fit to WHO weight standard of European infants over time. Arch Dis Child. 2016;101(5):455–460. doi: 10.1136/archdischild-2015-309594
- Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995;854:1–452.
- García Iñiguez JA, Vásquez-Garibay EM, García Contreras A, Romero-Velarde E, Troyo Sanromán R. Assessment of anthropometric indicators in children with cerebral palsy according to the type of motor dysfunction and reference standard. Nutr Hosp. 2017;34(2):315–322. doi: 10.20960/nh.353
- Ruiz Brunner MLM, Cuestas E, von Kries R, et al. Growth patterns in children and adolescents with cerebral palsy from Argentina and Germany. Sci Rep. 2023;13(1):8947. doi: 10.1038/s41598-023-34634-6
- Jahan I, Muhit M, Hardianto D, et al. Epidemiology of Malnutrition among Children with Cerebral Palsy in Low- and Middle-Income Countries: Findings from the Global LMIC CP Register. Nutrients. 2021;13(11):3676. doi: 10.3390/nu13113676
- Romero B, Robinson KG, Batish M, Akins RE. An Emerging Role for Epigenetics in Cerebral Palsy. J Pers Med. 2021;11(11):1187. doi: 10.3390/jpm11111187
- Fudvoye J, Parent AS. Secular trends in growth. Ann Endocrinol (Paris). 2017;78(2):88–91. doi: 10.1016/j.ando.2017.04.003
- Niere O, Spannemann L, Stenzel P, et al. Plasticity of human growth — a systematic review on psychosocial factors influencing growth. Anthropol Anz. 2020. doi: 10.1127/anthranz/2020/1223
- Karim T, Dossetor R, Huong Giang NT, et al. Data on cerebral palsy in Vietnam will inform clinical practice and policy in low and middle-income countries. Disabil Rehabil. 2022;44(13):3081–3088. doi: 10.1080/09638288.2020.1854872
- Rakhmaeva RF, Kamalova AA, Ayupova VA. Assessment of anthropometric parameters and body composition in children with cerebral palsy. Rossijskij vestnik perinatologii i pediatrii. 2019;64(5):204–208. (In Russ.) doi: 10.21508/1027-4065-201964-5-204-208
- Arnaud C, Ehlinger V, Delobel-Ayoub M, et al. Trends in Prevalence and Severity of Pre/Perinatal Cerebral Palsy Among Children Born Preterm From 2004 to 2010: A SCPE Collaboration Study. Front Neurol. 2021;12:624884. doi: 10.3389/fneur.2021.624884
- Al-Jabri BA, Al-Amri AS, Jawhari AA, Sait RM, Talb RY. Prevalence, Types, and Outcomes of Cerebral Palsy at a Tertiary Center in Jeddah, Saudi Arabia. Cureus. 2022;14(8):e27716. doi: 10.7759/cureus.27716
- Popkov D, editor. Understanding in children with cerebral palsy: orthopedic problems. New York: NOVA Science Publishers; 2020. 351 р.
- Leite HR, Jindal P, Malek SA, Rosenbaum P. Research on Children With Cerebral Palsy in Low- and Middle-Income Countries. Pediatr Phys Ther. 2022;34(4):551–555. doi: 10.1097/PEP.0000000000000949
- Fatkhulislamov RR, Gatamov OI, Mammadov UF, Popkov DA. Assessment of the condition of patients with spastic forms of cerebral palsy during the transition to an adult network of medical and preventive institutions: a cross-sectional study. Genij ortopedii. 2023;29(4):376–381. (In Russ.) doi: 10.18019/1028-4427-2023-29-4-376-381
- Zmanovskaya VA, Levitina EV, Popkov DA, Butorina MN, Pavlova OL. Long-term use of botulinum toxin type A preparation: dysport in complex rehabilitation of children with spastic forms of cerebral palsy. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2014;114(7):33–36. (In Russ.) EDN: STXUJZ
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