Hoffa’s infrapatellar fatty body volume in patients with knee osteoarthritis: dependence on body mass index
- Authors: Atoian V.A.1, Zolotov A.S.1, Zinkova E.A.1, Sadkovskii A.M.1
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Affiliations:
- Far Eastern Federal University
- Issue: Vol 32, No 1 (2025)
- Pages: 127-135
- Section: Original study articles
- URL: https://journal-vniispk.ru/0869-8678/article/view/290976
- DOI: https://doi.org/10.17816/vto631685
- ID: 290976
Cite item
Abstract
BACKGROUND: Gonarthrosis is the most common form of osteoarthritis (OA) and chronic low-grade inflammation plays a central role in its pathogenesis. Obesity plays an important role in the development of gonarthrosis — it is also favoured by the presence of a relatively large fat depot in the knee joint — the infrapatellar fat pad (IPFP) — which releases pro-inflammatory cytokines and causes local inflammation in the knee joint. There is conflicting data on the relationship between IPFP volume, body mass index (BMI) and stage of gonarthrosis. Given the significant prevalence of OA in the population and the limited options for its effective treatment, it seems relevant to further investigate the role of BMI in the pathogenesis of gonarthrosis, which may further contribute to the development of new targeted therapeutic strategies.
AIM: To evaluate the relationship between IPFP volume, BMI and stage of gonarthrosis in order to improve the effectiveness of preventive counselling and the possibility of further development of new treatment approaches.
MATHERIALS AND METHODS: We retrospectively analysed the data of magnetic resonance imaging of the knee joints performed on 32 patients with gonarthrosis in 2022-2023 at the Centre for Radiological Diagnostics of the FEFU Medical Centre (Vladivostok, Primorsky Krai). The patients were divided into two groups according to their BMI.
RESULTS: The mean IPFP volume for all patients in both groups was 33.01±8.79 cm3. Statistically significant differences were found when analysing the IPFP volume in men and women. Linear correlation analysis of the relationship between Hoffa's fat pad volume and OA stage in the female group showed a moderate inverse relationship and statistical significance. Multivariate statistical analysis showed that IPFP volume and BMI were most closely related to each other compared to other variables. No statistically significant differences in IPFP volume were found between the normal and increased BMI groups. A moderate negative correlation was found between BMI volume and OA stage in overweight patients. IPFP volume correlated with BMI in non-obese patients and weakly negatively in obese patients.
CONCLUSIONS: In the present study, greater IPFP volume was observed in overweight and obese patients compared to those with normal BMI, but these differences were not statistically significant. In patients with gonarthrosis, IPFP volume was associated with comorbid obesity, gender, age, height and weight. These data may be useful in developing individualised approaches to the prevention and treatment of OA.
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##article.viewOnOriginalSite##About the authors
Varsik A. Atoian
Far Eastern Federal University
Author for correspondence.
Email: atoian.va@dvfu.ru
ORCID iD: 0000-0002-2259-8950
SPIN-code: 5219-9183
postgraduate student
Russian Federation, 10, building M, Ajax settlement, Russian Island, 690922 VladivostokAleksandr S. Zolotov
Far Eastern Federal University
Email: dalexpk@gmail.com
ORCID iD: 0000-0002-0045-9319
SPIN-code: 3925-9025
MD, Dr. Sci. (Medicine), professor
Russian Federation, 10, building M, Ajax settlement, Russian Island, 690922 VladivostokEkaterina A. Zinkova
Far Eastern Federal University
Email: k762000@mail.ru
ORCID iD: 0000-0003-0873-1505
SPIN-code: 1531-4964
student
Russian Federation, 10, building M, Ajax settlement, Russian Island, 690922 VladivostokAlexey M. Sadkovskii
Far Eastern Federal University
Email: lehasadkowskij2000@gmail.com
ORCID iD: 0009-0006-8651-5727
SPIN-code: 9549-5093
student
Russian Federation, 10, building M, Ajax settlement, Russian Island, 690922 VladivostokReferences
- Osteoarthritis [Internet]. World Health Organization [cited 19 November 2023]. Available from: https://www.who.int/ru/news-room/fact-sheets/detail/osteoarthritis
- Grässel S, Muschter D. Recent advances in the treatment of osteoarthritis. F1000Research. 2020;9:325. doi: 10.12688/f1000research.22115.1
- Wei G, Lu K, Umar M, et al. Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms. Bone Research. 2023;11(1):63. doi: 10.1038/s41413-023-00301-9
- Knights AJ, Redding SJ, Maerz T. Inflammation in osteoarthritis: the latest progress and ongoing challenges. Current opinion in rheumatology. 2023;35(2):128–134. doi: 10.1097/BOR.0000000000000923
- Reyes C, Leyland KM, Peat G, et al. Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis: A Population-Based Cohort Study. Arthritis & Rheumatology. 2016;68(8):1869–1875. doi: 10.1002/art.39707
- Zeng N, Yan ZP, Chen XY, et al. Infrapatellar Fat Pad and Knee Osteoarthritis. Aging and Disease. 2020;11(5):1317–1328. doi: 10.14336/AD.2019.1116
- Zolotov AS, Zinkova EA, Atoian VA. Hoffa’s fat pad, Hoffa’s disease, Hoffa’s fracture: the history of eponyms. N.N. Priorov Journal of Traumatology and Orthopedics. 2023;30(3):367−374. (In Russ.). doi: 10.17816/vto409584
- Korneva YuS, Borisenko MB. Role of Infrapatellar Fat Tissue in the Pathogenesis of Knee Osteoarthritis: A Review. Traumatology and Orthopedics of Russia. 2023;29(4):147–155. (In Russ.). doi: 10.17816/2311-2905-15999
- Wickham MQ, Erickson GR, Gimble JM, et al. Multipotent stromal cells derived from the infrapatellar fat pad of the knee. Clin Orthop Relat Res. 2003;(412):196–212. doi: 10.1097/01.blo.0000072467.53786.ca
- Gavrilyuk VV. Ultrasound signs of Hoffa’s disease of the knee joint. Actual problems of the humanities and natural sciences. 2012;2:255–259. (In Russ.). EDN: OWZKNP
- Chuckpaiwong B, Charles HC, Kraus VB, et al. Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI. Journal of Orthopaedic Research. 2010;28(9):1149–1154. doi: 10.1002/jor.21125
- De Jong AJ, Klein-Wieringa IR, Andersen SN, et al. Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP). Arthritis Res Ther. 2017;19(1):186. doi: 10.1186/s13075-017-1395-9
- Burda B, Steidle-Kloc E, Dannhauer T, et al. Variance in infra-patellar fat pad volume: Does the body mass index matter? — Data from osteoarthritis initiative participants without symptoms or signs of knee disease. Annals of Anatomy — Anatomischer Anzeiger. 2017;213:19–24. doi: 10.1016/j.aanat.2017.04.004
- Steidle-Kloc E, Dannhauer T, Wirth W, et al. Responsiveness of Infrapatellar Fat Pad Volume Change to Body Weight Loss or Gain: Data from the Osteoarthritis Initiative. Cells Tissues Organs. 2018;205:53–62. doi: 10.1159/000485833
- Ragab E, Serag D. Infrapatellar fat pad area on knee MRI: does it correlate with the extent of knee osteoarthritis? Egypt J Radiol Nucl Med. 2021;52(2). doi: 10.1186/s43055-020-00383-z
- Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894(I–XII):1–253.
- Roemer FW, Jarraya M, Felson DT, et al. Magnetic resonance imaging of Hoffa’s fat pad and relevance for osteoarthritis research: a narrative review. Osteoarthritis and Cartilage. 2016;24(3):383–397. doi: 10.1016/j.joca.2015.09.018.
- Valiullin DR. Morphology of the fatty body of the knee joint in mature people and its development in prenatal ontogenesis [dissertation]. Ufa; 2003. Available from: https://www.dissercat.com/content/morfologiya-zhirovogo-tela-kolennogo-sustava-u-lyudei-zrelogo-vozrasta-i-ego-razvitie-v-pren. (In Russ). EDN: NHMFBB
- Ezure T, Amano S. Adiponectin and leptin up-regulate extracellular matrix production by dermal fibroblasts. Biofactors. 2007;31(3–4):229–236. doi: 10.1002/biof.5520310310
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