An Association Study of rs10462021 Polymorphism in the Clock Gene PERIOD3 and Different Clinical Types of Depression

Abstract

Circadian rhythms play an important role in the regulation of body metabolism, since the most important biochemical and physiological processes in the body are subjected to diurnal fluctuations. The transcription factor PERIOD3 encoded by the PER3 gene is one of the key components of the circadian negative transcription loop and, upon interaction with other proteins, affects the activity of the circadian clock. We aimed at studying genotype and allele frequencies of rs10462021 in the PER3 gene between the controls (N = 259) and different clinical types of depressive disorder, namely, depressive disorder (F32.1, 41.2) (N = 208) and recurrent depressive disorder (F 33.1) (N = 150), as well as patients with a history of suicide attempts (N = 100). No significant differences in distributions of genotype or allele frequencies between the groups were detected (p > 0.05). Therefore, there was no significant contribution of rs10462021 in the PER3 gene in the development of depressive disorder or various clinical types of depression.