Email this article Polymorphism of genes of the antioxidant system in the development of predispositions to lung cancer
- Authors: Titov R.A.1, Minina V.I.1,2, Soboleva O.A.1, Ryzhkova A.V.1, Kulemin Y.E.1,2, Voronina E.N.1,3
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Affiliations:
- Federal Research Center of Coal and Coal Chemistry, Siberian Branch
- Department of Genetics
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
- Issue: Vol 53, No 8 (2017)
- Pages: 903-909
- Section: Medical Genetics
- URL: https://journal-vniispk.ru/1022-7954/article/view/188397
- DOI: https://doi.org/10.1134/S1022795417080117
- ID: 188397
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Abstract
We analyzed the polymorphic loci in the genes of the antioxidant system enzymes, such as GSTP1 (313A>G and 341C>T), MnSOD (47С>Т), GPx1 (599C>T), and CAT (–262C>>T), among 497 residents of Kemerovo oblast (Western Siberia, Russia). The analysis of the single-locus effects demonstrated a significant protective effect of the major C allele in the GPx1 (599C>T) locus. The MDR analysis of the gene-gene interactions showed that the GPx1 and the CAT genes work in close cooperation and mutually reinforce the risk of development of squamous cell lung cancer among the inhabitants of the industrial region.
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About the authors
R. A. Titov
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Author for correspondence.
Email: ruslan-tito00@rambler.ru
Russian Federation, Kemerovo, 650065
V. I. Minina
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Department of Genetics
Email: ruslan-tito00@rambler.ru
Russian Federation, Kemerovo, 650065; Kemerovo, 650043
O. A. Soboleva
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: ruslan-tito00@rambler.ru
Russian Federation, Kemerovo, 650065
A. V. Ryzhkova
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: ruslan-tito00@rambler.ru
Russian Federation, Kemerovo, 650065
Yu. E. Kulemin
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Department of Genetics
Email: ruslan-tito00@rambler.ru
Russian Federation, Kemerovo, 650065; Kemerovo, 650043
E. N. Voronina
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: ruslan-tito00@rambler.ru
Russian Federation, Kemerovo, 650065; Novosibirsk, 630090
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