Draft genome sequencing and analysis of mutations of Streptomyces fradiae strain ATCC19609-Olg4R, resistant to (33S)-33-deoxy-33-thiocyanatooligomycin А
- Authors: Bekker O.B.1, Vatlin A.A.1, Lysenkova L.N.2, Shchekotikhin A.E.2, Danilenko V.N.1
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Affiliations:
- Vavilov Institute of General Genetics
- Gauze Research Institute of New Antibiotics
- Issue: Vol 53, No 9 (2017)
- Pages: 1048-1051
- Section: Short Communications
- URL: https://journal-vniispk.ru/1022-7954/article/view/188450
- DOI: https://doi.org/10.1134/S1022795417090034
- ID: 188450
Cite item
Abstract
Data of draft genome sequencing of Streptomyces fradiae-АТСС19609-Olg4R strain, resistant to (33S)-33-deoxy-33-thiocyanatooligomycin A, are presented. Comparative analysis of the genomes of S. fradiae wild-type strain ATCC19609 and S. fradiae strain ATCC19609-Olg4R showed the single nucleotide substitution that led to A(600)T change in the conservative P-loop NTPase region of class IV helicase gene, which, probably, promoted the resistance of S. fradiae strain ATCC19609-Olg4R to (33S)-33-deoxy-33-thiocyanatooligomycin A.
About the authors
O. B. Bekker
Vavilov Institute of General Genetics
Author for correspondence.
Email: obbekker@mail.ru
Russian Federation, Moscow, 119991
A. A. Vatlin
Vavilov Institute of General Genetics
Email: obbekker@mail.ru
Russian Federation, Moscow, 119991
L. N. Lysenkova
Gauze Research Institute of New Antibiotics
Email: obbekker@mail.ru
Russian Federation, Moscow, 119021
A. E. Shchekotikhin
Gauze Research Institute of New Antibiotics
Email: obbekker@mail.ru
Russian Federation, Moscow, 119021
V. N. Danilenko
Vavilov Institute of General Genetics
Email: obbekker@mail.ru
Russian Federation, Moscow, 119991
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