Draft genome sequencing and analysis of mutations of Streptomyces fradiae strain ATCC19609-Olg4R, resistant to (33S)-33-deoxy-33-thiocyanatooligomycin А


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Abstract

Data of draft genome sequencing of Streptomyces fradiae-АТСС19609-Olg4R strain, resistant to (33S)-33-deoxy-33-thiocyanatooligomycin A, are presented. Comparative analysis of the genomes of S. fradiae wild-type strain ATCC19609 and S. fradiae strain ATCC19609-Olg4R showed the single nucleotide substitution that led to A(600)T change in the conservative P-loop NTPase region of class IV helicase gene, which, probably, promoted the resistance of S. fradiae strain ATCC19609-Olg4R to (33S)-33-deoxy-33-thiocyanatooligomycin A.

About the authors

O. B. Bekker

Vavilov Institute of General Genetics

Author for correspondence.
Email: obbekker@mail.ru
Russian Federation, Moscow, 119991

A. A. Vatlin

Vavilov Institute of General Genetics

Email: obbekker@mail.ru
Russian Federation, Moscow, 119991

L. N. Lysenkova

Gauze Research Institute of New Antibiotics

Email: obbekker@mail.ru
Russian Federation, Moscow, 119021

A. E. Shchekotikhin

Gauze Research Institute of New Antibiotics

Email: obbekker@mail.ru
Russian Federation, Moscow, 119021

V. N. Danilenko

Vavilov Institute of General Genetics

Email: obbekker@mail.ru
Russian Federation, Moscow, 119991

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