Email this article Role of Gene-Gene Interactions in the Chromosomal Instability in Workers at Coal Thermal Power Plants
- Authors: Savchenko Y.A.1, Minina V.I.1,2, Bakanova M.L.1, Ryzhkova A.V.1, Soboleva O.A.1, Kulemin Y.E.1,2, Voronina E.N.3, Glushkov A.N.1,2, Vafin I.A.4
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Affiliations:
- Federal Research Center of Coal and Coal Chemistry, Siberian Branch
- Chair of Genetics
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
- Kemerovo Regional Blood Center
- Issue: Vol 54, No 1 (2018)
- Pages: 91-102
- Section: Medical Genetics
- URL: https://journal-vniispk.ru/1022-7954/article/view/188780
- DOI: https://doi.org/10.1134/S1022795418010106
- ID: 188780
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Abstract
The 23 polymorphic variants in genes encoding the enzymes of xenobiotics biotransformation (CYP1A1 (rs4646903), CYP1A2 (rs762551), GSTP1 (rs1138272, rs1695), GSTM1 (del), and GSTT1 (del)), DNA repair (XRCC1 (rs25489, rs25487), APEX1 (rs1130409), hOGG1 (rs1052133), ADPRT (rs1136410), XPD (rs13181), XPG (rs17655), XPC (rs2228001), ATM (rs1801516), NBS (rs1805794), XRCC2 (rs3218536), and XRCC3 (rs861539)), antioxidant system (MnSOD (rs4880) and GPx1 (rs1050450)), cell cycle control and apoptosis (TP53 (rs1042522)), DNA methylation (MTHFR (rs1801133) and MTR (rs1805087)), and chromosomal aberrations in lymphocytes in the workers at thermal power plants were analyzed. We found that allelic variants in the CYP1A1 (rs4646903), hOGG1 (rs1052133), XRCC1 (rs25487), and APEX1 (rs1130409) genes were associated with an increased level of chromosomal aberrations in workers. Informative models of gene-gene interactions including CYP1A1 (rs4646903, T>C), CYP1A2 (rs762551, C>A), GSTT1 (del); XRCC1 (rs25487, G>A), MTHFR (rs1801133, C>T), GSTT1 (del); XRCC1 (rs25487, G>A), APEX1 (rs1130409, T>G), TP53 (rs1042522, G>C) determining the formation of the increased frequency of chromosomal aberrations in the workers at coal thermal power plants were discovered.
About the authors
Ya. A. Savchenko
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Author for correspondence.
Email: yasavchenko@ya.ru
Russian Federation, Kemerovo, 650099
V. I. Minina
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Chair of Genetics
Email: yasavchenko@ya.ru
Russian Federation, Kemerovo, 650099; Kemerovo, 650000
M. L. Bakanova
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: yasavchenko@ya.ru
Russian Federation, Kemerovo, 650099
A. V. Ryzhkova
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: yasavchenko@ya.ru
Russian Federation, Kemerovo, 650099
O. A. Soboleva
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: yasavchenko@ya.ru
Russian Federation, Kemerovo, 650099
Yu. E. Kulemin
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Chair of Genetics
Email: yasavchenko@ya.ru
Russian Federation, Kemerovo, 650099; Kemerovo, 650000
E. N. Voronina
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: yasavchenko@ya.ru
Russian Federation, Novosibirsk, 630090
A. N. Glushkov
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Chair of Genetics
Email: yasavchenko@ya.ru
Russian Federation, Kemerovo, 650099; Kemerovo, 650000
I. A. Vafin
Kemerovo Regional Blood Center
Email: yasavchenko@ya.ru
Russian Federation, Kemerovo, 650000
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